Cushing’s syndrome is a rare disease that results from prolonged exposure to supraphysiological levels of glucocorticoids. Severe and rapidly progressive cases are often, but not exclusively, attributable to ectopic ACTH secretion. Extreme hypercortisolism usually has florid metabolic consequences and is associated with an increased infectious and thrombotic risk. The authors report on a case of a 51-year-old male that presented with severe Cushing’s syndrome secondary to an ACTH-secreting pituitary macroadenoma, whose diagnostic workup was affected by concurrent subclinical multifocal pulmonary infectious nodules. The case is noteworthy for the atypically severe presentation of Cushing’s disease, and it should remind the clinician of the possible infectious and thrombotic complications associated with Cushing’s syndrome.
Severe Cushing’s syndrome is not always caused by ectopic ACTH secretion.
Hypercortisolism is a state of immunosuppression, being associated with an increased risk for opportunistic infections.
Infectious pulmonary infiltrates may lead to imaging diagnostic dilemmas when investigating a suspected ectopic ACTH secretion.
Cushing’s syndrome carries an increased thromboembolic risk that may even persist after successful surgical management.
Antibiotic and venous thromboembolism prophylaxis should be considered in every patient with severe Cushing’s syndrome.
Udaya M KabadiVeteran Affairs Medical Center and Broadlawns Medical Center, Des Moines University of Osteopathic Medicine, Des Moines, Iowa, USA University of Iowa, Carver College of Medicine, Iowa City, Iowa, USA Medicine and Endocrinology, University of Iowa, Iowa City, Iowa, USA Des Moines University, Des Moines, Iowa, USA
Diabetic ketoacidosis (DKA) is commonly encountered in clinical practice. The current case is a unique and rare presentation of DKA as the initial manifestation of Cushing’s disease secondary to ACTH-secreting pituitary adenoma. Appropriate management as elaborated in the article led to total remission of diabetes as well as the Cushing’s disease.
DKA is a serious and potentially life-threatening metabolic complication of diabetes mellitus.
Some well-known precipitants of DKA include new-onset T1DM, insulin withdrawal and acute illness.
In a patient presenting with DKA, the presence of a mixed acid–base disorder warrants further evaluation for precipitants of DKA.
We present a rare case of DKA as an initial manifestation of Cushing’s disease secondary to ACTH-producing pituitary adenoma.