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Eline van der Valk, Tom Tobe, Aline Stades and Alex Muller

Summary

A 53-year-old male presented with recurrent calcium oxalate kidney stones as a first sign of underlying acromegaly, which vanished when his acromegaly was controlled. The exact mechanism behind hypercalciuria and urolithiasis in acromegaly is not yet clear. By discussing this case, a short overview of the pathophysiology of hypercalciuria in acromegaly and practical insights are given.

Learning points

  • Hypercalciuria is a common finding in acromegaly.

  • There are only few reports describing hypercalciuric kidney stones in acromegaly.

  • We assume that in acromegaly there is a primary role of IGF1-mediated, PTH-independent increase in calcitriol synthesis resulting in hypercalciuric kidney stones.