Filter

Refine by subject

Refine by date

—
  • Print
  • Save
  • Print

Diagnosis and Treatment > Medication

You are looking at 1 - 1 of 1 items for :

  • Insulin lispro x
  • Sulphonylureas x
Clear All
Akihiko Ando Division of Endocrinology and Metabolism, Department of Internal Medicine, Jichi Medical University, Tochigi, Japan

Search for other papers by Akihiko Ando in
Google Scholar
PubMed Close
,
Shoichiro Nagasaka Division of Endocrinology and Metabolism, Department of Internal Medicine, Jichi Medical University, Tochigi, Japan
Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Showa University Fujigaoka Hospital, Kanagawa Japan

Search for other papers by Shoichiro Nagasaka in
Google Scholar
PubMed Close
, and
Shun Ishibashi Division of Endocrinology and Metabolism, Department of Internal Medicine, Jichi Medical University, Tochigi, Japan

Search for other papers by Shun Ishibashi in
Google Scholar
PubMed Close

Summary

We report a case of a woman with diabetes mellitus caused by a genetic defect in ABCC8-coding sulfonylurea receptor 1 (SUR1), a subunit of the ATP-sensitive potassium (KATP) channel protein. She was diagnosed with diabetes at 7 days after birth. After intravenous insulin drip for 1 month, her hyperglycaemia remitted. At the age of 13 years, her diabetes relapsed, and after that she had been treated by intensive insulin therapy for 25 years with relatively poor glycaemic control. She was switched to oral sulfonylurea therapy and attained euglycaemia. In addition, her insulin secretory capacity was ameliorated gradually.

Learning points:

  • Genetic testing should be considered in any individuals or family with diabetes that occurred within the first year or so of life.

  • Sulfonylurea can achieve good glycaemic control in patients with KATP channel mutations by restoring endogenous insulin secretion, even if they were treated with insulin for decades.

  • Early screening and genetic testing are important to improve the prognosis of patients with neonatal diabetes mellitus arising from ABCC8 or KCNJ11 mutation.

Taxonomy:
Clinical Overview, Hormone, Insulin, Condition/ Syndrome, Hyperglycaemia, Neonatal diabetes, Patient Demographics, Age, Adult, Gender, Female, Ethnicity, White, Country of Treatment, Japan, Diagnosis and Treatment, Signs and Symptoms, Fatigue, Hyperglycaemia, Polydipsia, Investigation, C-peptide (24-hour urine), C-peptide (blood), GADA, Glucagon, Glucose (blood, fasting), Glucose tolerance (oral), Haemoglobin A1c, Insulin, Molecular genetic analysis, Urinalysis, Medication, Gliclazide, Insulin, Insulin Aspart, Insulin lispro, Sulphonylureas, Related Disciplines, Genetics, Publication Details, Case Report Type, Unusual effects of medical treatment
DOI:
https://doi.org/10.1530/EDM-18-0005
Volume/Issue:
Volume 2018: Issue 1
Open access