Filter

Refine by subject

Refine by date

—
  • Print
  • Save
  • Print

Patient Demographics

You are looking at 1 - 1 of 1 items for :

  • Iran, Islamic Republic of x
Clear All
Rishi Raj Pikeville Medical Center, Pikeville, Kentucky, USA

Search for other papers by Rishi Raj in
Google Scholar
PubMed Close
,
Samaneh Hasanzadeh Bushehr University of Medical Sciences, Bushehr, Iran

Search for other papers by Samaneh Hasanzadeh in
Google Scholar
PubMed Close
,
Mitra Dashtizadeh Bushehr University of Medical Sciences, Bushehr, Iran

Search for other papers by Mitra Dashtizadeh in
Google Scholar
PubMed Close
,
Mohammadreza Kalantarhormozi Bushehr University of Medical Sciences, Bushehr, Iran

Search for other papers by Mohammadreza Kalantarhormozi in
Google Scholar
PubMed Close
,
Katayoun Vahdat Bushehr University of Medical Sciences, Bushehr, Iran

Search for other papers by Katayoun Vahdat in
Google Scholar
PubMed Close
,
Mohammad Hossein Dabbaghmanesh Shiraz University of Medical Sciences, Shiraz, Iran

Search for other papers by Mohammad Hossein Dabbaghmanesh in
Google Scholar
PubMed Close
,
Iraj Nabipour Bushehr University of Medical Sciences, Bushehr, Iran

Search for other papers by Iraj Nabipour in
Google Scholar
PubMed Close
,
Mohammdreza Ravanbod Shiraz University of Medical Sciences, Shiraz, Iran

Search for other papers by Mohammdreza Ravanbod in
Google Scholar
PubMed Close
,
Majid Assadi Bushehr University of Medical Sciences, Bushehr, Iran

Search for other papers by Majid Assadi in
Google Scholar
PubMed Close
,
Basir Hashemi Shiraz University of Medical Sciences, Shiraz, Iran

Search for other papers by Basir Hashemi in
Google Scholar
PubMed Close
, and
Kamyar Asadipooya University of Kentucky, Lexington, Kentucky, USA

Search for other papers by Kamyar Asadipooya in
Google Scholar
PubMed Close

Summary

Oncogenic osteomalacia secondary to glomus tumor is extremely rare. Localization of causative tumors is critical as surgical resection can lead to a complete biochemical and clinical cure. We present a case of oncogenic osteomalacia treated with resection of glomus tumor. A 39-year-old woman with a history of chronic sinusitis presented with chronic body ache and muscle weakness. Biochemical evaluation revealed elevated alkaline phosphatase hypophosphatemia, increased urinary phosphate excretion, low calcitriol, and FGF23 was unsuppressed suggestive of oncogenic osteomalacia. Diagnostic studies showed increase uptake in multiple bones. Localization with MRI of paranasal sinuses revealed a sinonasal mass with concurrent uptake in the same area on the octreotide scan. Surgical resection of the sinonasal mass was consistent with the glomus tumor. The patient improved both clinically and biochemically postoperatively. Along with the case of oncogenic osteomalacia secondary to a glomus tumor, we have also discussed in detail the recent development in the diagnosis and management of oncogenic osteomalacia.

Learning points

  • Tumor-induced osteomalacia is a rare cause of osteomalacia caused by the secretion of FGF23 from mesenchymal tumors.

  • Mesenchymal tumors causing TIO are often difficult to localize and treat.

  • Resection of the tumor can result in complete resolution of biochemical and clinical manifestations in a very short span of time.

  • Glomus tumor can lead to tumor induced osteomalacia and should be surgically treated.

Taxonomy:
Clinical Overview, Gland/Organ, Bone, Topic, Bone, Patient Demographics, Age, Adult, Gender, Female, Ethnicity, Other, Country of Treatment, Iran, Islamic Republic of, Related Disciplines, General practice, Nephrology, Oncology, Otolaryngology, Radiology/Rheumatology, Publication Details, Case Report Type, New disease or syndrome: presentations/diagnosis/management
DOI:
https://doi.org/10.1530/EDM-20-0202
Volume/Issue:
Volume 2021: Issue 1
Open access