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Valeria de Miguel Departments of Endocrinology, Metabolism and Nuclear Medicine

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Andrea Paissan Departments of Endocrinology, Metabolism and Nuclear Medicine

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Patricio García Marchiñena Departments of Urology, Metabolism and Nuclear Medicine

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Alberto Jurado Departments of Urology, Metabolism and Nuclear Medicine

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Mariana Isola Pathology, Buenos Aires, Argentina

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José Alfie Hypertension Unit of Hospital Italiano de Buenos Aires, Buenos Aires, Argentina

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Patricia Fainstein-Day Departments of Endocrinology, Metabolism and Nuclear Medicine

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Summary

We present the case of a 25-year-old male with a history of neurofibromatosis type 1 and bilateral pheochromocytoma 4 years after kidney transplantation that was successfully treated with simultaneous bilateral posterior retroperitoneoscopic adrenalectomy.

Learning points:

  • Hypertensive patients with NF1 should always be screened for pheochromocytoma.

  • Pheochromocytoma is rarely associated with transplantation, but it must be ruled out in patients with genetic susceptibility.

  • Posterior retroperitoneoscopic adrenalectomy (PRA) allows more direct access to the adrenal glands, especially in patients with previous abdominal surgeries.

Taxonomy:
Clinical Overview, Gland/Organ, Adrenal, Topic, Adrenal, Hormone, Metanephrines, Condition/ Syndrome, Neurofibromatosis, Phaeochromocytoma, Patient Demographics, Age, Adolescent/young adult, Gender, Male, Ethnicity, Hispanic or Latino - Central American or South American, Country of Treatment, Argentina, Diagnosis and Treatment, Signs and Symptoms, Genu varum, Headache, Hypertension, Kidney dysplasia, Neurofibromas, Palpitations, Renal failure, Skin pigmentation - spotty, Sweating, Tachycardia, Investigation, Blood pressure, Creatinine, CT scan, Kidney function, Metanephrines (urinary), Normetanephrine, Intervention, Adrenalectomy, Kidney transplantation, Resection of tumour, Medication, Alpha-blockers, Amlodipine, Beta-blockers, Doxazosin, Fludrocortisone, Labetalol, Methylprednisolone, Mineralocorticoids, Prednisone, Related Disciplines, Nephrology, Publication Details, Case Report Type, Insight into disease pathogenesis or mechanism of therapy
DOI:
https://doi.org/10.1530/EDM-18-0162
Volume/Issue:
Volume 2019: Issue 1
Open access
Oscar D Bruno Division of Endocrinology
Fundacion de Endocrinologia

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Ricardo Fernández Pisani Division of Neurosurgery, Hospital de Clínicas, Universidad de Buenos Aires, Buenos Aires, Argentina

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Gabriel Isaac Division of Endocrinology

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Armando Basso Division of Neurosurgery, Hospital de Clínicas, Universidad de Buenos Aires, Buenos Aires, Argentina

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Summary

The role of mechanical forces influencing the growth of a pituitary adenoma is poorly understood. In this paper we report the case of a young man with hyperprolactinaemia and an empty sella secondary to hydrocephalia, who developed a macroprolactinoma following the relief of high intraventricular pressure.

Learning points:

  • The volume of a pituitary tumour may be influenced not only by molecular but also by local mechanical factors.

  • Intratumoural pressure, resistance of the sellar diaphragm and intracranial liquid pressure may play a role in the final size of a pituitary adenoma.

  • The presence of hydrocephalus may hide a pituitary macroadenoma.

Taxonomy:
Clinical Overview, Gland/Organ, Pituitary, Topic, Pituitary, Hormone, Prolactin, Condition/ Syndrome, Hyperprolactinaemia, Macroprolactinoma, Pituitary adenoma, Patient Demographics, Age, Adolescent/young adult, Gender, Male, Ethnicity, White, Country of Treatment, Argentina, Diagnosis and Treatment, Signs and Symptoms, Aqueductal stenosis, Bradyphrenia, Erectile dysfunction, Hyperprolactinaemia, Libido reduction/loss, Papilloedema, Psychomotor retardation, Investigation, Cortisol, FSH, GH, Immunohistochemistry, Intracranial pressure, LH, MRI, Prolactin, Intervention, Resection of tumour, Transsphenoidal surgery, Medication, Bromocriptine, Cabergoline, Dopamine agonists, Glucocorticoids, Hydrocortisone, Levothyroxine, Testosterone, Related Disciplines, Neurology, Publication Details, Case Report Type, Unique/unexpected symptoms or presentations of a disease
DOI:
https://doi.org/10.1530/EDM-16-0157
Volume/Issue:
Volume 2017: Issue 1
Open access