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Diagnosis and Treatment > Signs and Symptoms

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  • Hyperoxaluria x
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Eline van der Valk Diakonessenhuis Utrecht, Department of Internal Medicine, Postbus 80250, 3508 TG Utrecht, The Netherlands

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Tom Tobe Diakonessenhuis Utrecht, Department of Internal Medicine, Postbus 80250, 3508 TG Utrecht, The Netherlands

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Aline Stades UMC Utrecht, Department of Endocrinology, Postbus 85500, 3508 GA Utrecht, The Netherlands

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Alex Muller Diakonessenhuis Utrecht, Department of Internal Medicine, Postbus 80250, 3508 TG Utrecht, The Netherlands

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Summary

A 53-year-old male presented with recurrent calcium oxalate kidney stones as a first sign of underlying acromegaly, which vanished when his acromegaly was controlled. The exact mechanism behind hypercalciuria and urolithiasis in acromegaly is not yet clear. By discussing this case, a short overview of the pathophysiology of hypercalciuria in acromegaly and practical insights are given.

Learning points

  • Hypercalciuria is a common finding in acromegaly.

  • There are only few reports describing hypercalciuric kidney stones in acromegaly.

  • We assume that in acromegaly there is a primary role of IGF1-mediated, PTH-independent increase in calcitriol synthesis resulting in hypercalciuric kidney stones.

Taxonomy:
Clinical Overview, Gland/Organ, Kidney, Pituitary, Topic, Pituitary, Hormone, IGF1, Condition/ Syndrome, Acromegaly, Nephrolithiasis, Pituitary adenoma, Urolithiasis, Patient Demographics, Age, Adult, Gender, Male, Ethnicity, White, Country of Treatment, Netherlands, Diagnosis and Treatment, Signs and Symptoms, Citraturia, Hypercalciuria, Hyperhidrosis, Hyperoxaluria, Hypoglycaemia, Insulin resistance, Obstructive sleep apnoea, Investigation, IGF1, MRI, Intervention, Transsphenoidal surgery, Medication, Somatostatin analogues, Publication Details, Case Report Type, Insight into disease pathogenesis or mechanism of therapy
DOI:
https://doi.org/10.1530/EDM-13-0001
Volume/Issue:
Volume 2013: Issue 1
Open access