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Diagnosis and Treatment > Signs and Symptoms

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Oscar D Bruno Division of Endocrinology
Fundacion de Endocrinologia

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Ricardo Fernández Pisani Division of Neurosurgery, Hospital de Clínicas, Universidad de Buenos Aires, Buenos Aires, Argentina

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Gabriel Isaac Division of Endocrinology

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Armando Basso Division of Neurosurgery, Hospital de Clínicas, Universidad de Buenos Aires, Buenos Aires, Argentina

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Summary

The role of mechanical forces influencing the growth of a pituitary adenoma is poorly understood. In this paper we report the case of a young man with hyperprolactinaemia and an empty sella secondary to hydrocephalia, who developed a macroprolactinoma following the relief of high intraventricular pressure.

Learning points:

  • The volume of a pituitary tumour may be influenced not only by molecular but also by local mechanical factors.

  • Intratumoural pressure, resistance of the sellar diaphragm and intracranial liquid pressure may play a role in the final size of a pituitary adenoma.

  • The presence of hydrocephalus may hide a pituitary macroadenoma.

Taxonomy:
Clinical Overview, Gland/Organ, Pituitary, Topic, Pituitary, Hormone, Prolactin, Condition/ Syndrome, Hyperprolactinaemia, Macroprolactinoma, Pituitary adenoma, Patient Demographics, Age, Adolescent/young adult, Gender, Male, Ethnicity, White, Country of Treatment, Argentina, Diagnosis and Treatment, Signs and Symptoms, Aqueductal stenosis, Bradyphrenia, Erectile dysfunction, Hyperprolactinaemia, Libido reduction/loss, Papilloedema, Psychomotor retardation, Investigation, Cortisol, FSH, GH, Immunohistochemistry, Intracranial pressure, LH, MRI, Prolactin, Intervention, Resection of tumour, Transsphenoidal surgery, Medication, Bromocriptine, Cabergoline, Dopamine agonists, Glucocorticoids, Hydrocortisone, Levothyroxine, Testosterone, Related Disciplines, Neurology, Publication Details, Case Report Type, Unique/unexpected symptoms or presentations of a disease
DOI:
https://doi.org/10.1530/EDM-16-0157
Volume/Issue:
Volume 2017: Issue 1
Open access