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Diagnosis and Treatment > Signs and Symptoms

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Aishah Ekhzaimy Department of Medicine and College of Medicine, King Saud University, Riyadh, Saudi Arabia

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Afshan Masood Obesity Research Center, and College of Medicine, King Saud University, Riyadh, Saudi Arabia

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Seham Alzahrani Department of Medicine and College of Medicine, King Saud University, Riyadh, Saudi Arabia

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Waleed Al-Ghamdi Department of Medicine and College of Medicine, King Saud University, Riyadh, Saudi Arabia

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Daad Alotaibi Department of Medicine and College of Medicine, King Saud University, Riyadh, Saudi Arabia

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Muhammad Mujammami Department of Medicine and College of Medicine, King Saud University, Riyadh, Saudi Arabia

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Summary

Central diabetes insipidus (CDI) and several endocrine disorders previously classified as idiopathic are now considered to be of an autoimmune etiology. Dermatomyositis (DM), a rare autoimmune condition characterized by inflammatory myopathy and skin rashes, is also known to affect the gastrointestinal, pulmonary, and rarely the cardiac systems and the joints. The association of CDI and DM is extremely rare. After an extensive literature search and to the best of our knowledge this is the first reported case in literature, we report the case of a 36-year-old male with a history of CDI, who presented to the hospital’s endocrine outpatient clinic for evaluation of a 3-week history of progressive facial rash accompanied by weakness and aching of the muscles.

Learning points:

  • Accurate biochemical diagnosis should always be followed by etiological investigation.

  • This clinical entity usually constitutes a therapeutic challenge, often requiring a multidisciplinary approach for optimal outcome.

  • Dermatomyositis is an important differential diagnosis in patients presenting with proximal muscle weakness.

  • Associated autoimmune conditions should be considered while evaluating patients with dermatomyositis.

  • Dermatomyositis can relapse at any stage, even following a very long period of remission.

  • Maintenance immunosuppressive therapy should be carefully considered in these patients.

Taxonomy:
Clinical Overview, Gland/Organ, Hypothalamus, Kidney, Pituitary, Thyroid, Topic, Diabetes, Hormone, Antidiuretic Hormone, Prolactin, Testosterone, Thyroxine (T4), TSH, Condition/ Syndrome, Autoimmune disorders, Diabetes insipidus - neurogenic/central, Hypothyroidism, Patient Demographics, Age, Adolescent/young adult, Gender, Male, Ethnicity, Asian - other, Country of Treatment, Saudi Arabia, Diagnosis and Treatment, Signs and Symptoms, Diabetes insipidus, Erythema, Hypogonadism, Hypothyroidism, Myalgia, Myasthaenia, Nocturia, Oedema, Polydipsia, Polyuria, Rash, Investigation, Antinuclear antibody, C-reactive protein, Creatine kinase, Electromyography, Erythrocyte sedimentation rate, FT4, MRI, Prolactin, Sodium, Testosterone, TSH, Urine osmolality, White blood cell count, Medication, Desmopressin, Levothyroxine, Methylprednisolone, Related Disciplines, Dermatology, General practice, Nephrology, Radiology/Rheumatology, Publication Details, Case Report Type, Unique/unexpected symptoms or presentations of a disease
DOI:
https://doi.org/10.1530/EDM-19-0070
Volume/Issue:
Volume 2020: Issue 1
Open access