Search Results

You are looking at 1 - 1 of 1 items for :

  • Author: Sofia Pappa x
  • Patient Demographics x
  • Case Report Type x
  • Gland/Organ x
  • Related Disciplines x
  • Publication Details x
Clear All Modify Search
Nikitas S Skarakis Unit of Endocrinology and Diabetes Center, ‘G. Gennimatas’ General Hospital, Athens, Greece

Search for other papers by Nikitas S Skarakis in
Google Scholar
PubMed
Close
,
Irene Papadimitriou Unit of Endocrinology and Diabetes Center, ‘G. Gennimatas’ General Hospital, Athens, Greece

Search for other papers by Irene Papadimitriou in
Google Scholar
PubMed
Close
,
Labrini Papanastasiou Unit of Endocrinology and Diabetes Center, ‘G. Gennimatas’ General Hospital, Athens, Greece

Search for other papers by Labrini Papanastasiou in
Google Scholar
PubMed
Close
,
Sofia Pappa Department of Pathology, ‘G. Gennimatas’ General Hospital, Athens, Greece

Search for other papers by Sofia Pappa in
Google Scholar
PubMed
Close
,
Anastasia Dimitriadi Department of Pathology, ‘G. Gennimatas’ General Hospital, Athens, Greece

Search for other papers by Anastasia Dimitriadi in
Google Scholar
PubMed
Close
,
Ioannis Glykas Department of Urology, General Hospital of Athens ‘G Gennimatas’, Athens, Greece

Search for other papers by Ioannis Glykas in
Google Scholar
PubMed
Close
,
Konstantinos Ntoumas Department of Urology, General Hospital of Athens ‘G Gennimatas’, Athens, Greece

Search for other papers by Konstantinos Ntoumas in
Google Scholar
PubMed
Close
,
Penelope Lampropoulou Department of Radiology, General Hospital of Athens ‘G Gennimatas’, Athens, Greece

Search for other papers by Penelope Lampropoulou in
Google Scholar
PubMed
Close
, and
Theodora Kounadi Unit of Endocrinology and Diabetes Center, ‘G. Gennimatas’ General Hospital, Athens, Greece

Search for other papers by Theodora Kounadi in
Google Scholar
PubMed
Close

Summary

Juxtaglomerular cell tumour (JGCT) is an unusually encountered clinical entity. A 33-year-old man with severe long-standing hypertension and hypokalaemia is described. The patient also suffered from polyuria, polydipsia, nocturia and severe headaches. On admission, laboratory investigation revealed hypokalaemia, kaliuresis, high aldosterone and renin levels, and the abdomen CT identified a mass of 4 cm at the right kidney. Kidney function was normal. Following nephrectomy, the histological investigation revealed the presence of a JGCT. Immunostaining was positive for CD34 as well as for smooth muscle actin and vimentin. Following surgery, a marked control of his hypertension with calcium channel blockers and normalization of the serum potassium, renin or aldosterone levels were reached. According to our findings, JGCT could be included in the differential diagnosis of secondary hypertension as it consists of a curable cause. The association of JGCT with hypertension and hypokalaemia focusing on the clinical presentation, diagnostic evaluation and management is herein discussed and a brief review of the existing literature is provided.

Learning points

  • Juxtaglomerular cell tumours (JGCT), despite their rarity, should be included in the differential diagnosis of secondary hypertension as they consist of a curable cause of hypertension.

  • JGCT could be presented with resistant hypertension along with hypokalaemia, kaliuresis and metabolic alkalosis. Early recognition and management can help to prevent cardiovascular complications.

  • Imaging (enhanced CT scans) may be considered as the primary diagnostic tool for the detection of renal or JGCT.

  • For the confirmation of the diagnosis, a histopathologic examination is needed.

Open access