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Clement Olukayode Aransiola and Arinola Ipadeola

. Figure 2 Tc-99m HMDP bone scan showing uptake in the skull, spine, sternum, the ribs, pelvis, right femur and tibia. Treatment He was treated with oral alendronate with combined oral vitamin D and calcium supplements. A repeat ALP

Open access

S A S Aftab, N Reddy, N L Owen, R Pollitt, A Harte, P G McTernan, G Tripathi, and T M Barber

while on this drug. Following her consent, weekly alendronate therapy was commenced on her with calcium and vitamin D supplementation. Her response to bisphosphonate therapy will be monitored at future appointments with repeat DEXA bone scans. She will

Open access

Christopher Muir, Anthony Dodds, and Katherine Samaras

were commenced. At age 33 years, a decline in bone mineral density prompted initiation of oral bisphosphonate therapy with alendronate 70 mg weekly. Serial bone mineral density measurements improved, and alendronate was ceased after 18 months of therapy

Open access

Ana Marina Moreira and Poli Mara Spritzer

dyslipidemia and osteoporosis, treated with simvastatin and alendronate, respectively. She was an active smoker (20 cigarettes/day for 34years) and had one sister with POI. She lived in Southern Brazil (city of Porto Alegre, latitude 30°). She also reported not

Open access

Jingjing Jiang, Mei Zhang, Ronghua He, Meiping Shen, and Wei Liu

mTc-MIBI. Treatment Serum calcium persisted around 3 mmol/l despite treatment with oral alendronate (70 mg, qw) and calcitonin shot (200 IU, qd). Neck exploration was subsequently performed and 40×30 mm parathyroid cyst was surgically

Open access

B Cangiano, C Cacciatore, L Persani, and M Bonomi

received radiotherapy and/or chemotherapy. Moreover, he had essential hypertension. In 2012, osteoporosis was diagnosed (femoral T-score: −1.52; vertebral T-score: −3.2) without evidence of skeletal fractures, and he was therefore prescribed alendronate

Open access

Michal Barabas, Isabel Huang-Doran, Debbie Pitfield, Hazel Philips, Manoj Goonewardene, Ruth T Casey, and Benjamin G Challis

disease. Regular medications included gliclazide, bisoprolol, alendronate, calcium and vitamin D. There was no family history of endocrinopathy (including multiple endocrine neoplasia), malignancy or premature cardiovascular disease. The patient consumed

Open access

N Chelaghma, J Rajkanna, J Trotman, G Fuller, T Elsey, SM Park, and SO Oyibo


Hypogonadotrophic hypogonadism is due to impaired or reduced gonadotrophin secretion from the pituitary gland. In the absence of any anatomical or functional lesions of the pituitary or hypothalamic gland, the hypogonadotrophic hypogonadism is referred to as idiopathic hypogonadotrophic hypogonadism (IHH). We present a case of a young lady born to consanguineous parents who was found to have IHH due to a rare gene mutation.

Learning points:

  • The genetic basis of a majority of cases of IHH remains unknown.
  • IHH can have different clinical endocrine manifestations.
  • Patients can present late to the healthcare service because of unawareness and stigmata associated with the clinical features.
  • Family members of affected individuals can be affected to varying degrees.
Open access

Ismael Capel, Elisabet Tasa-Vinyals, Albert Cano-Palomares, Irene Bergés-Raso, Lara Albert, Mercedes Rigla, and Assumpta Caixàs

q. 1 month, calcium 500 mg q.d., alendronate 70 mg q. 1 week, acenocumarol 4 mg (periodic dosing), amiodarone 200 mg q.d., torasemide 5 mg q.d., enalapril 5 mg q.d., letrozole 2.5 mg q.d., citalopram 10 mg q.d., acetaminophen on demand (up to 3 g q

Open access

Zaina Adnan, David Nikomarov, Michal Weiler-Sagie, and Noga Roguin Maor

.2 in the femur. He was treated previously by his family physician for 5 years with alendronate, vitamin D and calcium. In 2011, he was referred to orthopedic consultation for left hip pain. His physical examination and pelvic CT were normal. Medical