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Chrisanthi Marakaki, Anna Papadopoulou, Olga Karapanou, Dimitrios T Papadimitriou, Kleanthis Kleanthous and Anastasios Papadimitriou

–10 ng/dl); Δ4-androstenedione (Δ4A), 3.6 ng/ml (normal 0.1–0.2 ng/ml); DHEAS, 126 μg/dl (normal 0.5–19.4) and 11-deoxycortisol, 38.1 ng/ml (normal <6 ng/ml). Plasma ACTH was also elevated at 83.8 pg/ml (normal 5–60 pg/ml), whereas serum cortisol was

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N F Lenders and J R Greenfield

examinations were unremarkable. Investigation Initial investigations demonstrated normal full blood count, renal function and liver function. Serum hormonal studies (immunoassay) are summarised in Table 1 . Testosterone and androstenedione were

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Gautam Das, Vinay S Eligar, Jyothish Govindan and D Aled Rees

-hydroxyprogesterone (17-OHP) levels were elevated at 54.2 nmol/l (non-pregnancy range: follicular, 1–10 nmol/l and luteal, 1–20 nmol/l) in accordance with pregnancy. Serum DHEAS was normal (5.4 μmol/l; non-pregnancy range, 1.9–9.4 μmol/l) but both androstenedione (>35

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Himangshu S Bose, Alan M Rice, Brendan Marshall, Fadi Gebrail, David Kupshik and Elizabeth W Perry

mineralocorticoid therapy, ACTH and plasma renin activity (PRA) levels were elevated, progesterone, 17-hydroxyprogesterone, dihydroepiandrosterone and androstenedione levels were below the detectable range of the assays used, and the sodium was mildly low, while the

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T O’Shea, R K Crowley, M Farrell, S MacNally, P Govender, J Feeney, J Gibney and M Sherlock

hydroxylase deficiency, steroid precursors are diverted into androgen synthesis pathways leading to testosterone, androstenedione and 17OHP excess. The major treatment goals in adults with CAH include avoidance of adrenal crisis, prevention of adrenal and

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Ravi Kumar Menon, Francesco Ferrau, Tom R Kurzawinski, Gill Rumsby, Alexander Freeman, Zahir Amin, Márta Korbonits and Teng-Teng L L Chung

. Investigations Plasma metanephrines were normal, as was aldosterone/renin ratio. She had mildly elevated androstenedione level at 12.8 nmol/l (1.0–11.8). Her other androgen levels were within normal limits. The low-dose dexamethasone suppression test (LDDST

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Diana Oliveira, Mara Ventura, Miguel Melo, Sandra Paiva and Francisco Carrilho

-SO4 <0.2 µg/mL 0.35–4.3 Androstenedione <0.3 ng/mL 0.5–3.4 17-OHP 1.70 ng/mL 0.2–1.8 21-Hydroxylase antibodies Negative TSH 2.4 pg/mL 0.4–4.0 FT4 3.0 pg/mL 0.8–1.9 Thyroglobulin antibodies

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Jasmeet Kaur, Alan M Rice, Elizabeth O’Connor, Anil Piya, Bradley Buckler and Himangshu S Bose

/mL/h), progesterone was <0.10 ng/mL, 17-hydroxyprogesterone was <10 ng/dL (29–35 weeks gestational age normal range 26–568 ng/dL), dihydroepiandrosterone (DHEA) was <0.050 ng/mL (premature normal range <40 ng/mL) and androstenedione was <0.030 ng/mL (31–35 weeks

Open access

Asma Deeb, Hana Al Suwaidi, Salima Attia and Ahlam Al Ameri

.4). Her gonadotropin levels were high for her pubertal status and her karyotype was 46,XX. Patient 3: Her ACTH was 35 mcg/l and potassium 3.3 mmol/l. Her testosterone, DHEAS, androstenedione and 17 hydroxyprogesterone were undetectable. Karyotype was 46

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Judith Gerards, Michael M Ritter, Elke Kaminsky, Andreas Gal, Wolfgang Hoeppner and Marcus Quinkler

.8 (+) 17-OH-progesterone ng/mL 0.2–1.3 0.59 0.32 0.46 n.d. n.d. 0.4 (−) DHEA ng/mL 550–4100 83 (−) <50 (−) 53 (−) 110 (−) n.d. 41.4 (−) Androstenedione ng/mL 0.29–2.67 0.20 (−) 0.10 (−) 0.10 (−) 0