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N Jassam, N Amin, P Holland, R K Semple, D J Halsall, G Wark, and J H Barth

 750 pmol/l, with appropriate C-peptide levels of <94 pmol/l. Insulin and C-peptide levels vary greatly depending on glucose levels, but in patients with no anti-insulin antibodies the ratio is typically maintained at 1:5–1:10 (insulin:C-peptide). In

Open access

Pooja Sahni, Nitin Trivedi, and Abdulkadir Omer

elevated anti-insulin antibody levels. Typically, it is known to occur in patients exposed to insulin analogues ( 1 ). Other medications such as alpha lipoic acid ( 2 ) and sulfa-containing drugs such as procainamide, methimazole and hydralazine have also

Open access

Agnieszka Łebkowska, Anna Krentowska, Agnieszka Adamska, Danuta Lipińska, Beata Piasecka, Otylia Kowal-Bielecka, Maria Górska, Robert K Semple, and Irina Kowalska

Background Type B insulin resistance syndrome (TBIR) is a rare autoimmune disorder characterised by the development of anti-insulin receptor antibodies (AIRA). It most commonly leads to extreme insulin resistance with severe hyperglycaemia and

Open access

Marina Yukina, Nurana Nuralieva, Maksim Solovyev, Ekaterina Troshina, and Evgeny Vasilyev

hypoglycemia due to anti-insulin antibodies value of the free C-peptide assay . American Journal of Clinical Pathology 2014 142 689 – 693 . ( ) 12 Lupsa BC Chong AY Cochran EK Soos MA Semple RK Gorden

Open access

Nishant Raizada, S H Rahaman, D Kandasamy, and V P Jyotsna

polyethylene glycol (PEG) provides indirect evidence of anti-insulin antibody. This simple test can be done in any laboratory. The results may prevent the search for an insulinoma and instead guide the clinician toward a diagnosis of IAS. Case

Open access

A Veltroni, G Zambon, S Cingarlini, and M V Davì

Background Insulin autoimmune syndrome (IAS), also known as Hirata’s disease, is a rare autoimmune disorder characterised by hyperinsulinaemic hypoglycaemia associated with high titres of antibodies to endogenous insulin, in the absence of

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Chih-Ting Su and Yi-Chun Lin

with IAS often have underlying autoimmune disorders or have been exposed to certain drugs containing a sulfhydryl group, such as methimazole. In rare cases, insulin antibodies (IA) associated with exogenous insulin administration caused hypoglycemia

Open access

Hiromi Himuro, Takashi Sugiyama, Hidekazu Nishigori, Masatoshi Saito, Satoru Nagase, Junichi Sugawara, and Nobuo Yaegashi

anti-islet cell antibody 2 (ICA2). Therefore, this patient manifested DKA as a result of pregnancy-related autoimmune diabetes. In this case, we focused on differential diagnosis. Late pregnancy is characterized by a state of insulin resistance

Open access

Adriana de Sousa Lages, Isabel Paiva, Patrícia Oliveira, Francisco Portela, and Francisco Carrilho

were collected confirming the previous results: plasma glucose 38 mg/dL, plasma insulin 10 µIU/L and c-peptide 1.9 µg/mL with negative anti-insulin antibodies. During hospitalization, the patient had multiple daily episodes of hypoglycaemia mainly

Open access

Akira Kurozumi, Yosuke Okada, Tadashi Arao, Yusuke Miyazaki, Maiko Yoshikawa, Keiichi Torimoto, Satoshi Kubo, Shingo Nakayamada, and Yoshiya Tanaka

Background Acute-onset type 1 diabetes mellitus (AOT1DM) is associated with the reduction in endogenous insulin secretion soon after the onset, often making glycemic control difficult. Rituximab, an anti-CD20 monoclonal antibody that depletes