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Takuya Higashitani, Shigehiro Karashima, Daisuke Aono, Seigoh Konishi, Mitsuhiro Kometani, Rie Oka, Masashi Demura, Kenji Furukawa, Yuto Yamazaki, Hironobu Sasano, Takashi Yoneda, and Yoshiyu Takeda

masses. Case presentation A 62-year-old Japanese patient was treated for diabetes, hypertension, and dyslipidemia for 10 years. He was found unconscious and was admitted to a hospital. Investigation On presentation, his BP was 236/118 mmHg

Open access

Keita Tatsushima, Akira Takeshita, Shuji Fukata, Noriaki Fukuhara, Mitsuo Yamaguchi-Okada, Hiroshi Nishioka, and Yasuhiro Takeuchi

( GNAS ) that lead to thyrotoxicosis independent of TSH ( 3 ). AFTNs are more common in areas with iodine deficiencies and less common in areas with excessive iodine intake, including Japan. AFTNs usually present with findings of primary hyperthyroidism

Open access

Kei Ito, Jun Ito, Yuki Yamamoto, Rikako Nakajima, Masanao Fujii, Yukino Katakura, Aiko Muramatsu, Norio Takayashiki, Kazuhiro Toyama, Mineo Kurokawa, and Hiroaki Yagyu

Summary

A 61-year-old man developed central diabetes insipidus caused by mixed histiocytosis (MH) representing Langerhans cell histiocytosis overlapping with Erdheim–Chester disease. Bone, skin, vascular, and retroperitoneal involvements were also observed. Dynamic hormonal testing showed normal responses for anterior pituitary hormones, except for impaired secretion of growth hormone (GH). MRI of the brain showed thickening of the pituitary stalk with slightly reduced signal hyperintensity in the posterior pituitary lobe on T1-weighted imaging. During 2 years of follow-up without radical treatment for MH, imaging studies suggested extension of vascular and retroperitoneal involvements. In contrast, brain MRI did not show any particular interval changes, except for the disappearance of hyperintense signalling in the posterior pituitary lobe. Moreover, no other anterior pituitary dysfunctions beyond GH deficiency emerged during the 2 years of follow-up. The natural history of MH in this case is described, focusing on serial assessments of pituitary functions using dynamic tests.

Learning points

  • Erdheim–Chester disease and Langerhans cell histiocytosis overlapping as MH was described, focusing on pituitary functions.

  • MH caused both GH deficiency and central diabetes insipidus.

  • Despite a lack of radical therapy for MH, no other anterior pituitary dysfunctions emerged for 2 years.

  • Radiological images showed no particular interval changes in pituitary stalk lesions, while vascular and retroperitoneal involvements extended.

Open access

Nobuyuki Nishi, Ken Takeshima, Shuhei Morita, Hiroshi Iwakura, Masahiro Nishi, and Takaaki Matsuoka

Akamizu T Arima H . Diagnosis and treatment of autoimmune and IgG4-related hypophysitis: clinical guidelines of the Japan Endocrine Society . Endocrine Journal 2020 67 373 – 378 . ( https://doi.org/10.1507/endocrj.EJ19-0569 ) 5 Shikuma J

Open access

Tomomi Taguchi, Sachiko Kimizuka, and Koji Takano

( 11 ). The appearance score is lower in Japanese patients who undergo pharmaceutical therapy than in those who are treated with surgery alone ( 13 ). Compared to no treatment, treatment with lanreotide showed worsening of all AcroQoL scores( 14 ).The

Open access

Yuki Fujita, Daisuke Tanaka, Hisato Tatsuoka, Miho Matsubara, Takanori Hyo, Yoshiyuki Hamamoto, Toshiyuki Komiya, Nobuya Inagaki, Yutaka Seino, and Yuji Yamazaki

. Generally, MODY represents the insufficient insulin secretion with a lean phenotype, which is common to type 2 diabetes mellitus (T2DM) in Japanese patients ( 2 ). HNF1B mutation manifesting as MODY5 was first described in 1997 ( 3 ). In fact, MODY5 is

Open access

Shuhei Baba, Arina Miyoshi, Shinji Obara, Hiroaki Usubuchi, Satoshi Terae, Masao Sunahara, Takahiro Oshima, Kazuhito Misawa, Takahiro Tsuji, Bunya Takahashi, Yuto Yamazaki, Hironobu Sasano, and Norio Wada

.1016/s0022-3476(85)80297-3 ) 3 Omura M , Saito J , Yamaguchi K , Kakuta Y & Nishikawa T . Prospective study on the prevalence of secondary hypertension among hypertensive patients visiting a general outpatient clinic in Japan

Open access

Hiroki Nakajima, Yasuhiro Niida, Eriko Hamada, Kuwata Hirohito, Masahide Ota, Sadanori Okada, Takako Mohri, Yukako Kurematsu, Shigeto Hontsu, Shigeo Muro, and Yutaka Takahashi

Pharma and TAIHO Pharma. Funding This study was supported by the Ministry of Health, Labor and Welfare, Japan (Grants-in-Aid for Scientific Research on Hypothalamo-hypophyseal Disorders and Grants-in-Aid for Scientific Research on Endocrine

Open access

Mitsuhiro Kometani, Takashi Yoneda, Yuji Maeda, Masashi Oe, Yoshimichi Takeda, Takuya Higashitani, Daisuke Aono, Asuka Yoshino, Shigehiro Karashima, and Yoshiyu Takeda

Background A catecholamine secreting pheochromocytoma is a relatively rare neuroendocrine tumor that arises from chromaffin cells of the adrenal medulla. Pheochromocytoma accounts for less than 1% of all causes of hypertension. In Japan, it

Open access

A Veltroni, G Zambon, S Cingarlini, and M V Davì

pathological abnormalities of the pancreatic islets and prior exposure to exogenous insulin ( 1 ). The syndrome is relatively well known in Japan, whereas it is considered rare in the rest of Asia, and it is extremely uncommon in Western countries. After the