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Nishant Raizada, S H Rahaman, D Kandasamy and V P Jyotsna

, IAS is less commonly reported in western countries. In IAS, insulin antibodies develop without prior exposure to exogenous insulin. The patients often have underlying autoimmune disorders predisposed to the development of IAS. It is unclear why only

Open access

D Cappellani, C Sardella, M C Campopiano, A Falorni, P Marchetti and E Macchia

Background Insulin autoimmune syndrome (IAS) is a rare disease, firstly described by Hirata and colleagues in 1970 ( 1 ) and characterised by spontaneous hypoglycaemic episodes in the presence of high titer of insulin autoantibodies (IAAs) in

Open access

Laila Ennazk, Ghizlane El Mghari and Nawal El Ansari

autoimmune disorders, was admitted in intensive care for acute epigastric pain and vomiting. She had an impaired general condition and weight loss of 10 kg in 2 weeks. On examination, Glasgow Coma Scale was at 13/15. Blood pressure was at 120/80 mmHg and

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Åke Sjöholm, Maria João Pereira, Thomas Nilsson, Torbjörn Linde, Petros Katsogiannos, Jan Saaf and Jan W Eriksson

of prediabetes and overt type 2 diabetes in genetically predisposed individuals. Type B insulin resistance syndrome (TBIRS) is a very rare autoimmune disorder with acquired polyclonal autoantibodies against the insulin receptor, which results in

Open access

Aishah Ekhzaimy, Afshan Masood, Seham Alzahrani, Waleed Al-Ghamdi, Daad Alotaibi and Muhammad Mujammami

to occur as an isolated disorder or in association with other autoimmune diseases, especially, endocrine autoimmune diseases ( 4 , 5 , 6 ). Dermatomyositis (DM), another rare idiopathic inflammatory condition, also with an autoimmune etiology

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Ali A Zaied, Halis K Akturk, Richard W Joseph and Augustine S Lee

been on any systemic glucocorticoids. There was no personal or family history of pancreatitis, DM or other autoimmune disorders. Patient was afebrile and normotensive with a pulse of 88 beats per minute, respiratory rate of 28 breaths per minute and

Open access

A Veltroni, G Zambon, S Cingarlini and M V Davì

Background Insulin autoimmune syndrome (IAS), also known as Hirata’s disease, is a rare autoimmune disorder characterised by hyperinsulinaemic hypoglycaemia associated with high titres of antibodies to endogenous insulin, in the absence of

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M Horsey, P Hogan and T Oliver

Effects of Disease of the Supra-renal Capsules . London, UK : Samuel Highley , 1855 . 3 Neufeld M Blizzard RM. Polyglandular autoimmune disease. In Autoimmune Aspects of Endocrine Disorders , pp 357 – 365. London, UK : Academic Press

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Theresa Penger, Andrea Albrecht, Michaela Marx, Daniel Stachel, Markus Metzler and Helmuth G Dörr

malignant diseases and many nonmalignant disorders, such as autoimmune diseases ( 31 ). The cumulative incidence of secondary autoimmune disease after HSCT for primary autoimmune disease was 9.8% at 5 years ( 32 ). It has been speculated that dysregulation

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Shunsuke Funazaki, Hodaka Yamada, Kazuo Hara and San-e Ishikawa

Background Lymphocytic hypophysitis (LyH) is an autoimmune disorder characterized by lymphocyte infiltration into the pituitary gland and induction of chronic inflammation, leading to pituitary dysfunction. Its onset has been linked to