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Clement Olukayode Aransiola and Arinola Ipadeola

bisphosphonates to include pre-therapy levels of ALP and post-therapy ALP nadir (9) . Siris et al . (7) in a comparative study found that alendronate was superior to etidronate in the treatment of PDB. In that study, after 6 months of oral treatment with 40 mg

Open access

Reiner Jumpertz von Schwartzenberg, Ulf Elbelt, Manfred Ventz, Knut Mai, Tina Kienitz, Lukas Maurer, Thomas Rose, Jens C Rückert, Christian J Strasburger and Joachim Spranger

calcimimetics are more effective in lowering calcium levels and bear less side effects. Palliative medical therapy in parathyroid cancer patients today is mainly based on the use of intravenous bisphosphonates and calcimimetics such as cinacalcet hydrochloride

Open access

Mawson Wang, Catherine Cho, Callum Gray, Thora Y Chai, Ruhaida Daud and Matthew Luttrell

there is resistant hypercalcaemia. Bisphosphonates should be avoided in MAS, although, as in our case, the diagnosis is not always clear at the time of presentation. This case highlights the importance of recognising milk-alkali syndrome as a

Open access

Nikolaos Asonitis, Eva Kassi, Michalis Kokkinos, Ilias Giovanopoulos, Foteini Petychaki and Helen Gogas

of HHM remains a challenge. There are various agents such as calcitonin, bisphosphonates (BPs) and denosumab, which can be administered in addition to the intense hydration; however, there are cases that these agents can be ineffective. In such

Open access

B Cangiano, C Cacciatore, L Persani and M Bonomi

performed after 2 years of treatment showed an initial increase of bone mineral density, after the reported inefficacy of bisphosphonates and vitamin D supplementation. The patient also reported an improved quality of life and mood with restoration of libido

Open access

Nobuhiro Miyamura, Shuhei Nishida, Mina Itasaka, Hirofumi Matsuda, Takeshi Ohtou, Yasuhiro Yamaguchi, Daisuke Inaba, Sadahiro Tamiya and Tetsuo Nakano

report a new case, with diagnosis confirmed by bone biopsy and treated initially with a bisphosphonate, next with steroid therapy including intravenous pulse administration, and finally with direct acting antivirals (DAA) aiming at sustained virological

Open access

Nirusha Arnold, Victor O’Toole, Tien Huynh, Howard C Smith, Catherine Luxford, Roderick Clifton-Bligh and Creswell J Eastman

maintain the serum calcium within the normal reference range. The introduction of prednisone required insulin therapy to control hyperglycaemia. Many different therapies to decrease the hypercalcaemia were considered, including parenteral bisphosphonates

Open access

S A S Aftab, N Reddy, N L Owen, R Pollitt, A Harte, P G McTernan, G Tripathi and T M Barber

lifting or other physical activities that may put her at risk of further fracture. Prior to initiation onto bisphosphonate therapy, she was fully informed and counselled regarding the potential teratogenic effects of these agents and to avoid pregnancy

Open access

Christopher Muir, Anthony Dodds and Katherine Samaras

were commenced. At age 33 years, a decline in bone mineral density prompted initiation of oral bisphosphonate therapy with alendronate 70 mg weekly. Serial bone mineral density measurements improved, and alendronate was ceased after 18 months of therapy

Open access

Mona Abouzaid, Ahmed Al-Sharefi, Satish Artham, Ibrahim Masri, Ajay Kotagiri and Ashwin Joshi

radius bilaterally. Given the patients other morbidities, his PHPT was treated conservatively with monitoring of his biochemistry after a multidisciplinary team discussion. Bisphosphonates therapy was added with a prospective plan to initiate