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Katsumi Taki Department of Internal Medicine, Fujiyoshida Municipal Medical Center, Yamanashi, 403-0005, Japan

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Takahiko Kogai Department of Infection Control and Clinical Laboratory Medicine, Dokkyo Medical University, Tochigi, 321-0293, Japan

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Junko Sakumoto Department of Infection Control and Clinical Laboratory Medicine, Dokkyo Medical University, Tochigi, 321-0293, Japan

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Takashi Namatame Clinical Research Center, Dokkyo Medical University, Tochigi, 321-0293, Japan

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Akira Hishinuma Department of Infection Control and Clinical Laboratory Medicine, Dokkyo Medical University, Tochigi, 321-0293, Japan

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Background Calcium-sensing receptor (CASR), which is mainly expressed in parathyroid chief cells and renal tubular cells, regulates phospho-calcic homeostasis by regulating the secretion of parathyroid hormone (PTH) as well as renal calcium

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Florence Gunawan Barwon Health, Geelong University Hospital, Geelong, Victoria, Australia

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Elizabeth George Barwon Health, Geelong University Hospital, Geelong, Victoria, Australia

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Mark Kotowicz Barwon Health, Geelong University Hospital, Geelong, Victoria, Australia

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tubular excretion of calcium. Despite this aggressive therapy, the hypocalcaemia remained refractory ( Fig. 1 ). Oral dexamethasone 4 mg BD was trialed in an attempt to induce bone resorption. Figure 1 Graph demonstrating fluctuations in the serum

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Daniela Gallo Department of Medicine and Surgery, Endocrine Unit, University of Insubria, Varese, Italy

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Sara Rosetti Department of Medicine and Surgery, Endocrine Unit, University of Insubria, Varese, Italy

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Ilaria Marcon Department of Oncology, ASST dei Sette Laghi, Varese, Italy

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Elisabetta Armiraglio Pathology Unit, ASST Gaetano Pini, Centro Specialistico Ortopedico Traumatologico, Gaetano Pini-CTO, Milano, Italy

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Antonina Parafioriti Pathology Unit, ASST Gaetano Pini, Centro Specialistico Ortopedico Traumatologico, Gaetano Pini-CTO, Milano, Italy

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Graziella Pinotti Department of Oncology, ASST dei Sette Laghi, Varese, Italy

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Giuseppe Perrucchini I.R.C.C.S Istituto Ortopedico Galeazzi, Milano, Italy

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Bohdan Patera Department of Medicine and Surgery, Endocrine Unit, University of Insubria, Varese, Italy

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Linda Gentile Department of Medicine and Surgery, Endocrine Unit, University of Insubria, Varese, Italy

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Maria Laura Tanda Department of Medicine and Surgery, Endocrine Unit, University of Insubria, Varese, Italy

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Luigi Bartalena Department of Medicine and Surgery, Endocrine Unit, University of Insubria, Varese, Italy

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Eliana Piantanida Department of Medicine and Surgery, Endocrine Unit, University of Insubria, Varese, Italy

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other due to specific morphology, clinical and radiologic features, giant cell lesions include giant cell tumors of bone (GCTB), solid aneurysmal bone cysts, giant cell rich chondroblastoma, non-ossifying fibromas and brown tumors (BT). Demographic

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Marisa M Fisher Division of Pediatric Endocrinology, Department of Pediatrics, Riley Hospital for Children, Indiana University School of Medicine, 705 Riley Hospital Drive, Room 5960, Indianapolis, Indiana, 46220, USA

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Susanne M Cabrera Division of Pediatric Endocrinology, Department of Pediatrics, Medical College of Wisconsin, Children's Hospital of Wisconsin, 9000 W. Wisconsin Avenue, PO Box 1997, Milwaukee, Wisconsin, 53201, USA

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Erik A Imel Division of Pediatric Endocrinology, Department of Pediatrics, Riley Hospital for Children, Indiana University School of Medicine, 705 Riley Hospital Drive, Room 5960, Indianapolis, Indiana, 46220, USA
Division of Endocrinology, Department of Medicine, Indiana University School of Medicine, 541 North Clinical Drive, Indianapolis, Indiana, 46202, USA

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Barbieri AM & Spada A 2013 Pharmacology of the calcium sensing receptor . Clinical Cases in Mineral and Bone Metabolism 10 162 – 165 . Gannon AW Monk HM & Levine MA 2014 Cinacalcet monotherapy in

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S Hamidi Division of Endocrinology, Department of Medicine, Hôpital Maisonneuve-Rosemont, Montréal, Canada

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S Mottard Division of Orthopedic Surgery, Department of Surgery, Hôpital Maisonneuve-Rosemont, Montréal, Canada

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M J Berthiaume Department of Radiology, Hôpital Maisonneuve-Rosemont, Montréal, Canada

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J Doyon Department of Pathology, Hôpital Maisonneuve-Rosemont, Montréal, Canada

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M J Bégin Division of Endocrinology, Department of Medicine, Hôpital Maisonneuve-Rosemont, Montréal, Canada

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L Bondaz