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Kharis Burns, Darshika Christie-David, and Jenny E Gunton

Background The management of pituitary adrenocorticotrophin (ACTH) Cushing's disease involves surgery as the first-line intervention. Medical therapy may be introduced to control cortisol excess in circumstances where disease is not

Open access

Mimi Wong, Usman H Malabu, Ipeson Korah, and YongMong Tan

Background Cushing's disease (CD) is rare and relates to excess corticotropin secretion from a pituitary adenoma. Early diagnosis and treatment are important, as the duration of exposure to excess glucocorticoids is predictive of mortality ( 1

Open access

Takuma Hara, Hiroyoshi Akutsu, Tetsuya Yamamoto, Eiichi Ishikawa, Masahide Matsuda, and Akira Matsumura

Background Cushing's disease accounts for 4.7% of pituitary adenomas (1) , and typically patients show clinical symptoms of impaired glucose tolerance, hypertension, central obesity, moon face, osteoporosis, and psychosis (2) (3) . Gastric

Open access

Mawson Wang, Benjamin Jonker, Louise Killen, Yvonne Bogum, Ann McCormack, and Ramy H Bishay

Background Pituitary tumours are common, with an estimated prevalence of 16.7% based on autopsy and radiologic studies ( 1 ). The relative prevalence of adrenocorticotropin (ACTH)-secreting (corticotroph) tumours, or Cushing’s disease, is only

Open access

Stephanie Wei Ping Wong, Yew Wen Yap, Ram Prakash Narayanan, Mohammad Al-Jubouri, Ashley Grossman, Christina Daousi, and Yahya Mahgoub

diagnosis of Cushing’s disease arising from a large pituitary macroadenoma. Figure 1 Coronal view of MRI pituitary showing a right-sided pituitary macroadenoma on T1 (upper figure) and T2 (lower figure) weighted images. Treatment

Open access

Sharmin Jahan, M A Hasanat, Tahseen Mahmood, Shahed Morshed, Raziul Haq, and Md Fariduddin

subpopulation of NFA is characterized by a lack of hypercortisolemia, no clinical evidence of Cushing disease (CD), and positive immunostaining for adrenocorticotropic hormone (ACTH) ( 3 ). These distinct subtypes of pituitary adenomas represent approximately 20

Open access

Sajjad Ahmad, Thomas Best, Andrew Lansdown, Caroline Hayhurst, Fiona Smeeton, Steve Davies, and Aled Rees

steroid excess is very rare. We report a case of SEL in a teenage patient with Cushing’s disease who developed spastic paraparesis post-trans-sphenoidal surgery and aim to review the current literature. To our knowledge this is only the third reported case

Open access

Regina Streuli, Ina Krull, Michael Brändle, Walter Kolb, Günter Stalla, Marily Theodoropoulou, Annette Enzler-Tschudy, and Stefan Bilz

Background Pituitary corticotroph adenomas (Cushing’s disease) account for the vast majority of cases diagnosed with ACTH-dependent hypercortisolism and only 5–10% result from ectopic sources of ACTH and very rarely CRH. Since up to 50% of

Open access

Satoru Sakihara, Kazunori Kageyama, Satoshi Yamagata, Ken Terui, Makoto Daimon, and Toshihiro Suda

Background Cushing's syndrome is characterized by signs and symptoms resulting from chronic glucocorticoid excess. Adrenocorticotropic hormone (ACTH)-dependent Cushing's syndrome includes Cushing's disease and ectopic ACTH syndrome (EAS), with

Open access

Shinobu Takayasu, Shingo Murasawa, Satoshi Yamagata, Kazunori Kageyama, Takeshi Nigawara, Yutaka Watanuki, Daisuke Kimura, Takao Tsushima, Yoshiyuki Sakamoto, Kenichi Hakamada, Ken Terui, and Makoto Daimon

thrombosis with CS have not been described ( 8 ). Furthermore, an increase in cardiovascular risk has been observed, even in the cases of remission of CS ( 9 ). The risk for postoperative events increases in patients with Cushing’s disease ( 10 ). The source