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Pedro Marques, Kavinga Gunawardana and Ashley Grossman

peroxidase antibodies <35 IU/ml; glucose 3.5 mmol/l and HbA1c 5.3%. Bilirubin, alanine transaminase, alkaline phosphatase, albumin, uric acid, creatinine and full blood count were within the normal reference range. The 24-h urine output prior to desmopressin

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Ramesh Srinivasan, Stephen Ball, Martin Ward-Platt, David Bourn, Ciaron McAnulty and Tim Cheetham

became hyponatraemic while on desmopressin (DDAVP) medication. Case presentation The index case was thought to be drinking excessively by his parents at 3 months of age. Father had been diagnosed with CDI in adolescence and was on regular DDAVP

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Ricardo A Macau, Tiago Nunes da Silva, Joana Rego Silva, Ana Gonçalves Ferreira and Pedro Bravo

ventilated for airway protection due to impaired consciousness. Standard therapy with 5% IV dextrose, hydrochlorothiazide 50 plus amiloride 5 mg and desmopressin 2 mg IV bid was initiated. No significant reduction in the urine output was observed after each

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Natassia Rodrigo and Samantha Hocking

of her blood pressure. Following confirmation of DI with the water deprivation test, she was commenced on desmopressin nasal spray, which resulted in decreased urine output. Outcome and follow-up On discharge creatinine had improved to 73 mmol

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Apostolos K A Karagiannis, Fotini Dimitropoulou, Athanasios Papatheodorou, Stavroula Lyra, Andreas Seretis and Andromachi Vryonidou

treated with desmopressin (60μg orally thrice daily). Antibiotic treatment continued; the patient was treated with linezolid and meropenem for 1month intravenously followed by linezolid 1200mg and moxifloxacin 400mg orally daily for another month. One

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Mara Ventura, Leonor Gomes, Joana Rosmaninho-Salgado, Luísa Barros, Isabel Paiva, Miguel Melo, Diana Oliveira and Francisco Carrilho

-like protein 4 (SALL4), and it was cytokeratin CAM 5.2 and β-hCG negative. Treatment Treatment with testosterone in a dosage of 125 mg each 4 weeks, hydrocortisone 10 mg at wake time and 5 mg in the afternoon and desmopressin 0.06 mg/day was started

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Florence Gunawan, Elizabeth George and Adam Roberts

urine osmolality performed at that stage. Desmopressin nasal spray, twice at night, was instituted with relief of symptoms and normalization of his sodium. An attempt at lowering the dose resulted in a return of symptoms and hypernatremia. Three weeks

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Despoina Manousaki, Cheri Deal, Jean Jacques De Bruycker, Philippe Ovetchkine, Claude Mercier and Nathalie Alos

(dexamethasone for 3 days, then prednisone), was initiated upon reception of the results of the biopsy. Immediately after surgery, the patient developed persistent hypernatremia and polyuria compatible with diabetes insipidus and was started on oral desmopressin

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Alicia R Jones, Alan McNeil, Christopher Yates, Bala Krishnamurthy and Peter S Hamblin

was treated with intranasal desmopressin 10 µg BD with resolution of DI symptoms and was commenced on testosterone transdermal gel. Due to the discordant results of the CSF βhCG levels depending on the assay used, a decision was made to continue

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Derick Adams and Philip A Kern

. Outcome and follow-up Postoperatively, her urine output increased to 440mL/h with serum sodium levels reaching 154mmol/L. She required administration of intravenous fluid and several doses of intravenous desmopressin to correct her polyuria and normalise