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Simone Pederzoli, Giorgia Spaggiari, Giuditta Bernardelli, Francesco Mattioli, Cinzia Baldessari, Antonino Maiorana, Vincenzo Rochira, and Daniele Santi

-018-9529-4 ) 6 Kalampokas E Payne F Nomikos A Gurumurthy M An update on the use of immunohistochemistry and molecular pathology in the diagnosis of pre-invasive and malignant lesions in gynecological oncology . Gynecologic Oncology 2018 150 378 – 3

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João José Nunes Roque, Irina Borisovna Samokhvalova Alves, Ana Maria de Almeida Paiva Fernandes Rodrigues, and Maria João Bugalho

hyperandrogenism in a postmenopausal woman whose final diagnosis was established by histology. Case presentation A 62-year-old woman presented in the Endocrine Clinic with a 9-month history of new-onset and progressive hair loss, scalp hair thinning

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Shuhei Baba, Arina Miyoshi, Shinji Obara, Hiroaki Usubuchi, Satoshi Terae, Masao Sunahara, Takahiro Oshima, Kazuhito Misawa, Takahiro Tsuji, Bunya Takahashi, Yuto Yamazaki, Hironobu Sasano, and Norio Wada

hypertension in WS varied from 5 to 70% in different series ( 4 , 5 , 6 ), and there is a lifetime risk of developing arterial hypertension of 50% ( 5 ). The mean age at diagnosis of hypertension varied widely in the literature, from 4.7 to 38.8 years ( 4

Open access

Serena Khoo, Greta Lyons, Andrew Solomon, Susan Oddy, David Halsall, Krishna Chatterjee, and Carla Moran

postpartum thyroiditis ( 9 ). Here we describe a complex case of Hashimoto’s thyroiditis evolving to Graves’ disease with discordant thyroid function, eventually resulting in diagnosis of coexistent FDH, highlighting challenges in diagnosis and management

Open access

Mitsuhiro Kometani, Takashi Yoneda, Yuji Maeda, Masashi Oe, Yoshimichi Takeda, Takuya Higashitani, Daisuke Aono, Asuka Yoshino, Shigehiro Karashima, and Yoshiyu Takeda

pheochromocytomas ( 2 ). Pheochromocytoma is associated with various cardiovascular diseases such as hypertension, arrhythmia, cardiomyopathy, and acute coronary syndrome (ACS) ( 3 ). The symptoms associated with ACS are occasionally found in patients with

Open access

Angelo Paci, Ségolène Hescot, Atmane Seck, Christel Jublanc, Lionel Mercier, Delphine Vezzosi, Delphine Drui, Marcus Quinkler, Martin Fassnacht, Eric Bruckert, Marc Lombès, Sophie Leboulleux, Sophie Broutin, and Eric Baudin

Background Monitoring plasma mitotane levels is recommended in the follow-up of patients with unresectable adrenocortical carcinoma (ACC) to look for a therapeutic window of 14–20mg/L to optimize benefit over risk and avoid toxicities ( 1

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Ramesh Srinivasan, Stephen Ball, Martin Ward-Platt, David Bourn, Ciaron McAnulty, and Tim Cheetham

possibility of inter-current infection but the diagnosis was revised to include one of water intoxication and the DDAVP was stopped. In light of the fact that the biochemistry at the time of DDAVP initiation had not been diagnostic of CDI, it was felt

Open access

Eva Krčálová, Jiří Horáček, Lubomír Kudlej, Viera Rousková, Blanka Michlová, Irena Vyhnánková, Jiří Doležal, Jaroslav Malý, and Pavel Žák

in the lower part of the right lobe. In addition, several small cysts (up to 5mm) in the upper part of the right lobe were described. The appearance of the left lobe was unremarkable and lymphadenopathy was not present. Static thyroid gland

Open access

Marta Araujo Castro, Ainhoa Abad López, Luz Martín Fragueiro, and Nuria Palacios García

loss of staining for parafibromin, a product of the HRPT2 gene (involved in the pathogenesis of PC) has a sensitivity of 67–96% and a specificity of 99% for the diagnosis of PC. As a result, a negative staining is practically diagnostic of PC and a

Open access

Elke Thijs, Katrien Wierckx, Stefaan Vandecasteele, and Annick Van den Bruel

of active extra-adrenal tuberculosis ( 5 ). Adrenal biopsy is generally necessary in these patients to confirm diagnosis. Case presentation A 42-year-old man with complaints of muscle soreness and an increased pigmentation of the skin was