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Geetanjali Kale, Elaine M Pelley and Dawn Belt Davis

morning and 2.5 mg in the evening and fludrocortisone 0.1 mg daily since adolescence. The patient was obese and denied a history of precocious puberty, diabetes, hypertension, or excess virilization. He is married and had never attempted to have children

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Diana Oliveira, Adriana Lages, Sandra Paiva and Francisco Carrilho

/mL, cortisol 0.24 μg/dL (5–25) ( Figure 1 ). Hydrocortisone was uptitrated to 20 mg + 10 mg + 10 mg. Fludrocortisone 0.05 mg id was prescribed, however, the patient did not take it because of teratogenicity concerns. Figure 1 ACTH and cortisol values

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Peter Taylor, Sasan Dehbozorgi, Arshiya Tabasum, Anna Scholz, Harsh Bhatt, Philippa Stewart, Pranav Kumar, Mohd S Draman, Alastair Watt, Aled Rees, Caroline Hayhurst and Stephen Davies

remained persistently high between 3 and 5 L a day over this time. Fludrocortisone was therefore introduced at 75 µg bd and ultimately increased to 150 µg bd, which resulted in a substantial (threefold) fall in requirements for hypertonic saline that was

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M Baxter, S Gorick and F M Swords

test: cortisol level rose to 56 nmol/l at 30 min. Adrenal antibodies and ACTH and renin levels were not checked at that time. He was treated conventionally with hydrocortisone 20 mg on waking, 10 mg midafternoon and fludrocortisone 50 μg daily

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Elke Thijs, Katrien Wierckx, Stefaan Vandecasteele and Annick Van den Bruel

with primary adrenal insufficiency (PAI) and treatment with hydrocortisone (15 mg + 5 mg/day) and fludrocortisone (50 µg/day) was initiated. Figure 1 Hyperpigmentation of skin and mucosae. Table 1 Laboratory findings

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Lukas Burget, Laura Audí Parera, Monica Fernandez-Cancio, Rolf Gräni, Christoph Henzen and Christa E Flück

.1 ng/mL/h, ref. values: 1.4–7.8) with normal aldosterone (647 pmol/L; ref. values: 180.3–2385). Testing for 21-hydroxylase antibodies was negative. Replacement therapy with 50 µg fludrocortisone daily and 10 mg hydrocortisone (20 mg/m 2 /day) was

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Andromachi Vryonidou, Stavroula A Paschou, Fotini Dimitropoulou, Panagiotis Anagnostis, Vasiliki Tzavara and Apostolos Katsivas

polyserositis, methylprednisolone was replaced with hydrocortisone at a replacement dose of 15 mg in the morning and 5 mg in the afternoon for adrenal insufficiency. Fludrocortisone in a dose of 100 µg per day was also given. Discussion This is a very

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Nicholas R Zessis, Jennifer L Nicholas and Stephen I Stone

; PTT, partial thromboplastin time; WBC, white blood cell count. Treatment The patient was started on stress dose hydrocortisone (50 mg/m 2 /day divided three times daily) on day of life (DOL) two and fludrocortisone on DOL three (initially

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Anna Kopczak, Adrian-Minh Schumacher, Sandra Nischwitz, Tania Kümpfel, Günter K Stalla and Matthias K Auer

upper normal range with 4.7 mmol/L (normal range: 3.6–5 mmol/L). Addison’s disease was diagnosed, and the patient was immediately treated with hydrocortisone (HC) 20 mg/day and fludrocortisone 0.05 mg/day. However, despite adequate gluco- and mineralo

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Harris Trainer, Paul Hulse, Claire E Higham, Peter Trainer and Paul Lorigan

demonstrating bilateral increased FDG activity in the adrenals (right adrenal SUVmax = 5.2, left adrenal SUVmax = 5.4, background liver SUVmax = 2.7). Once established on hydrocortisone and fludrocortisone the patient’s symptoms resolved and serum