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Angelo Paci, Ségolène Hescot, Atmane Seck, Christel Jublanc, Lionel Mercier, Delphine Vezzosi, Delphine Drui, Marcus Quinkler, Martin Fassnacht, Eric Bruckert, Marc Lombès, Sophie Leboulleux, Sophie Broutin and Eric Baudin

performed using Unicel DXC Beckman Coulter Automate (Marseille, France). EP, etoposide-platin; F, fluorouracil; G, gemcitabine; PD, progressive disease; SD, stable disease. Investigation Influence of HCH and HTG on plasma o,p′ -DDD and o

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Dured Dardari, Alfred Penfornis and Agnes Hartemann

follow-up Both patients were followed-up for 12 months at the Diabetic Department of Centre Hopitalier Sud Francilien, Corbeil-Essonne France. Discussion The prevalence of CN varies between 0.1 and 0.4% in the diabetic population ( 6 ). This

Open access

Kamel Mohammedi, Charbel Abi Khalil, Sophie Olivier, Imane Benabad, Ronan Roussel and Michel Marre

Summary

Hypoglycemia is a common medical emergency. It is the most frequent complication induced by anti-diabetic treatment. However, it can be observed in other conditions unrelated to diabetes such as insulinoma, autoimmune disorders, and neoplasia. Herein, we report the case of a rare cause of severe and recurrent hypoglycemia in a 77-year-old woman with a malignant solitary fibrous tumor (MSFT). A 77-year-old woman was admitted to the emergency department for loss of consciousness induced by severe hypoglycemia. Her standard laboratory findings were unremarkable. HbA1c, albumin, renal, liver, thyroid, and adrenal function tests were normal. Cerebral CT scan was also normal. At the time of confirmed hypoglycemia, the serum level of insulin and C-peptide was low. On the basis of the past medical history and the absence of other comment etiologies, a paraneoplastic cause was suspected. Thus, the diagnosis of a non-islet cell tumor-induced hypoglycemia (NICTH) was established by the presence of incompletely processed precursors of IGF2 (big IGF2) in plasma electrophoresis. However, the IGF1 level was low. Therapy with corticosteroids improved hypoglycemia and clinical symptoms. NICTH is a rare cause of hypoglycemia. It should be considered in patients with mesenchymal or malignant epithelial tumors suffering from recurrent episodes of hypoglycemia. The diagnosis will be established in the case of low serum insulin concentrations and elevated levels of big IGF2. Treatment with corticosteroids, GH, or both can improve hypoglycemic symptoms and restore plasma glucose to normal levels.

Learning points

  • NICTH is a very rare condition that should be considered in patients known to have mesenchymal or malignant epithelial tumors and suffering from recurrent episodes of hypoglycemia.
  • The diagnosis of an NICTH is established on the basis of the hypoinsulinemic hypoglycemia, the MSFT history, and the presence of paraneoplastic secretion of IGF1 or an immature form of IGF2.
  • Treatment with corticosteroids, GH, or both can improve hypoglycemic symptoms and restore plasma glucose to normal levels in NICTH.

Open access

Taieb Ach, Perrine Wojewoda, Flora Toullet, Roxane Ducloux and Véronique Avérous

Summary

Multiple endocrine metastases are a rare but possible complication of lung adenocarcinoma (LAC). Pituitary metastasis is a rare condition with poor clinical expression. Diabetes insipidus (DI) is its most common presenting symptom. Here we report an original case of a pituitary stalk (PS) metastasis from LAC presenting as central DI followed by adrenal insufficiency (AI) from bilateral adrenal metastasis, without known evidence of the primary malignancy. A 45-year-old woman whose first clinical manifestations were polyuria and polydipsia was admitted. She was completely asymptomatic with no cough, no weight loss or anorexia. Chest radiography was normal. Brain MRI showed a thick pituitary stalk (PS). DI was confirmed by water restriction test and treated with vasopressin with great clinical results. Explorations for systemic and infectious disease were negative. Few months later, an acute AI led to discovering bilateral adrenal mass on abdominal CT. A suspicious 2.3 cm apical lung nodule was found later. Histopathological adrenal biopsy revealed an LAC. The patient received systemic chemotherapy with hormonal replacement for endocrinological failures by both vasopressin and hydrocortisone. We present this rare case of metastatic PS thickness arising from LAC associated with bilateral adrenal metastasis. Screening of patients with DI and stalk thickness for lung and breast cancer must be considered. Multiple endocrine failures as a diagnostic motive of LAC is a rare but possible circumstance.

Learning points:

  • Adrenal metastasis is a common location in lung adenocarcinoma; however, metastatic involvement of the pituitary stalk remains a rare occurrence, especially as a leading presentation to diagnose lung cancer.
  • The posterior pituitary and the infundibulum are the preferential sites for metastases, as they receive direct arterial blood supply from hypophyseal arteries.
  • Patients diagnosed with diabetes insipidus due to pituitary stalk thickness should be considered as a metastasis, after exclusion of the classical systemic and infectious diseases.
  • The diagnosis of an endocrinological metastatic primary lung adenocarcinoma for patients without respiratory symptoms is often delayed due to a lack of correlation between endocrinological symptoms and lung cancer.
  • The main originality of our case is the concomitant diagnosis of both endocrinological failures, as it was initiated with a diabetes insipidus and followed by an acute adrenal insufficiency.
Open access

C Mumby, J R E Davis, J Trouillas and C E Higham

(4) . There are two previous case reports of acromegaly due to co-secretion of GHRH by phaeochromocytoma (5) (6) . A recent series of such cases have been reported in France: 21 patients were identified with ectopic secretion of GHRH, 12 cases were

Open access

Ji Wei Yang and Jacques How

containing 100 mg/mL of potassium iodide and 50 mg/mL of iodine, was developed in 1829 by the French physician Jean Guillaume Auguste Lugol (1786–1851). François Magendie (1783–1855), a French physiologist, considered by many as a pioneer of experimental

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Caroline Bachmeier, Chirag Patel, Peter Kanowski and Kunwarjit Sangla

). In 2013, a larger French study was published by Bricaire and coworkers reporting molecular abnormalities in patients with PH. 20 index cases were identified and out of these 3 patients had a CDC73 gene deletion with only one of them expanding beyond

Open access

Benedetta Zampetti, Giorgia Simonetti, Roberto Attanasio, Antonio Silvani and Renato Cozzi

treatment in prolactinomas were described, most successful as this case. It was previously described that MGMT immunostaining in the tumor was predictive of treatment failure ( 6 , 7 ). However, the multicentric French study showed that this was not the

Open access

Alessandro Mantovani, Maddalena Trombetta, Chiara Imbriaco, Riccardo Rigolon, Lucia Mingolla, Federica Zamboni, Francesca Dal Molin, Dario Cioccoloni, Viola Sanga, Massimiliano Bruti, Enrico Brocco, Michela Conti, Giorgio Ravenna, Fabrizia Perrone, Vincenzo Stoico and Enzo Bonora

Medicine 362 1022 – 1029 . ( doi:10.1056/NEJMcp0910753 ) Grammatico L Baron S Rusch E Lepage B Surer N Desenclos JC Besnier JM 2008 Epidemiology of vertebral osteomyelitis in France

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Skand Shekhar, Sriram Gubbi, Georgios Z Papadakis, Naris Nilubol and Fady Hannah-Shmouni

: Tumours of Endocrine Tumors Ed R A DeLelils pp 139-142 2004 Lyon, France: IARC . 7 Icard P Goudet P Charpenay C Andreassian B Carnaille B Chapuis Y Cougard P Henry JF Proye C . Adrenocortical carcinomas: surgical trends and results