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Kingsley Okolie, Daniel Chen, Raf Ghabrial and Robert Schmidli

normal at <0.1–<3.1 mIU/L. The IGF-1 decreased in subsequent tests but remained elevated. Ultrasound of the neck revealed a small multi-nodular goitre. The largest nodule was situated within the posterior inferior aspect of the right lobe and exhibited

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S Pearson, C Donnellan, L Turner, E Noble, K Seejore and R D Murray

. The initial presentation was with the development of a rapidly enlarging goitre, which was noted by the patient’s primary care physician. This had been progressively increasing in size for the previous ten months. The patient described symptoms of

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Pradeep Vasudevan, Corrina Powell, Adeline K Nicholas, Ian Scudamore, James Greening, Soo-Mi Park and Nadia Schoenmakers

genetic ascertainment in the UK ( 2 ). Significant fetal hypothyroid goitre is a rare conse­quence of fetal dyshormonogenesis, and complications include polyhydramnios due to oesophageal compression and malpresentation due to neck hyperextension at

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Nicholas Woodhouse, Fatima Bahowairath and Omayma Elshafie

elective laparoscopic cholecystectomy and was referred to the endocrine unit as she had a large soft goitre and abnormal thyroid function test (TFT). She was being dialysed three times per week after having undergone nephrectomy four years ago for

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Joana Simões-Pereira, Rafael Adame Cabrera and Valeriano Leite

, with a recent onset of an increasing cervical mass without compressive symptoms. A multinodular goitre was detected and she was submitted to fine-needle aspiration cytology (FNAC) of one of the nodules, which revealed a colloid goitre. Detailed

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Gemma Xifra, Silvia Mauri, Jordi Gironès, José Ignacio Rodríguez Hermosa, Josep Oriola, Wifredo Ricart and José Manuel Fernández-Real

can exhibit signs of hyperthyroidism in one tissue and findings suggestive of hypothyroidism in other tissues according to the distribution of the different thyroid receptor subtypes. Goitre is reported to be the most common feature followed by sinus

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Ellena Cotton and David Ray

had regular scans of her thyroid, which revealed the expected multinodular goitre, and in 2018, she was diagnosed with a differentiated papillary carcinoma thyroid. Investigation Endocrinology assessment revealed raised serum prolactin at 1444

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Maria P Yavropoulou, Efstathios Chronopoulos, George Trovas, Emmanouil Avramidis, Francesca Marta Elli, Giovanna Mantovani, Pantelis Zebekakis and John G Yovos

investigation of his hypercalcitoninaemia on the ground of multinodular goitre (calcitonin >100 pg/mL in repeated measurements). The physical examination revealed an obese person (BMI: 39.7) with short stature (height: 165 cm) ( Table 1 ), round face, stocky

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Ravi Kumar Menon, Francesco Ferrau, Tom R Kurzawinski, Gill Rumsby, Alexander Freeman, Zahir Amin, Márta Korbonits and Teng-Teng L L Chung

not have symptoms or signs suggestive of phaeochromocytoma, glucocorticoid or androgen excess. She had multiple cutaneous neurofibromas, café-au-lait spots, axillary freckling, kyphoscoliosis, and severe myopia. She also had a multi-nodular goitre

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T Min, S Benjamin and L Cozma

and a diffusely enlarged goitre. He was in atrial fibrillation with heart rate of 165 beats/min, hypotensive with blood pressure of 90/54 mmHg and hypoxic requiring high-flow oxygen to maintain oxygen saturation of 92–94%. He had a raised jugular