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Khaled Aljenaee, Osamah Hakami, Colin Davenport, Gemma Farrell, Tommy Kyaw Tun, Agnieszka Pazderska, Niamh Phelan, Marie-Louise Healy, Seamus Sreenan and John H McDermott

and two beta chains. Circulating blood glucose binds to the N-terminal valine of the β-chain of haemoglobin A to form HbA1c ( 1 ) ( Fig. 1 ). In individuals with poorly controlled diabetes, and with higher than normal levels of circulating glucose, the

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Mirjam Eiswirth, Ewan Clark and Michael Diamond

) levels. It is associated with a significant pathological burden, and has been well established that poor glycaemic control correlates with increasing morbidity and mortality ( 1 ). Glycosylated haemoglobin (HbA1c) is a marker of glycaemic control