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Sarah Y Qian, Matthew J L Hare, Alan Pham, and Duncan J Topliss

features ( 2 ). Insulinomas classically present with fasting hypoglycaemia; however, the clinical presentation can be variable and delayed diagnosis is common. Despite considerable advances in localisation imaging, accurate surgical resection can be

Open access

S A A van den Berg and C G Krol

Background Non-islet cell tumour hypoglycaemia (NICTH) is a rare complication of malignancy. Although the exact incidence of NICTH is unknown, it is estimated to be about 1/4th of the incidence of insulinoma, but is probably underestimated

Open access

Seong Keat Cheah, David Halsall, Peter Barker, John Grant, Abraham Mathews, Shyam Seshadri, and Singhan Krishnan

/L. This was treated with bolus intravenous dextrose solution, which was then administered as continuous infusion during her inpatient stay due to recurrent hypoglycaemia. She was treated for lower respiratory tract infection, which was thought to be the

Open access

Kah-Yin Loke, Andrew Sng Anjian, Yvonne Lim Yijuan, Cindy Ho Wei Li, Maria Güemes, and Khalid Hussain

Background Hyperinsulinaemic hypoglycaemia (HH) from dysregulated insulin secretion of the pancreatic β-cells is an important cause of persistent neonatal hypoglycaemia. Mutations have been reported in the ABCC8 and KCNJ11 genes on

Open access

Ved Bhushan Arya, Jennifer Kalitsi, Ann Hickey, Sarah E Flanagan, and Ritika R Kapoor

Background Hyperinsulinaemic hypoglycaemia (HH) is the most frequent cause of severe and persistent hypoglycaemia in infants and children ( 1 ). It is characterised by inappropriate secretion of insulin in the presence of low blood glucose (BG

Open access

A Veltroni, G Zambon, S Cingarlini, and M V Davì

Background Insulin autoimmune syndrome (IAS), also known as Hirata’s disease, is a rare autoimmune disorder characterised by hyperinsulinaemic hypoglycaemia associated with high titres of antibodies to endogenous insulin, in the absence of

Open access

Sally K Abell, Jessie Teng, Anthony Dowling, Michael S Hofman, Richard J MacIsaac, and Nirupa Sachithanandan

(2) and 10–15% of insulinomas (1) may have widespread metastases at diagnosis. Symptomatic hypoglycaemia may be very difficult to control in malignant insulinoma. We report a case of recurrent inoperable metastatic pNET co-secreting both insulin

Open access

María Clemente, Alejandro Vargas, Gema Ariceta, Rosa Martínez, Ariadna Campos, and Diego Yeste

Background Hyperinsulinaemic hypoglycaemia of infancy (HHI) is the most frequent cause of persistent neonatal hypoglycaemia and hypoglycaemia in infancy and is caused by dysregulation in insulin secretion. Molecular bases are known in 50

Open access

Sarah Kiff, Carolyn Babb, Maria Guemes, Antonia Dastamani, Clare Gilbert, Sarah E Flanagan, Sian Ellard, John Barton, M Dattani, and Pratik Shah

Background Congenital hyperinsulinaemic hypoglycaemia (CHI) is the most common cause of persistent severe hypoglycaemia presenting in the neonatal period ( 1 ). The underlying cause of hyperinsulinism and the presence of diffuse or focal

Open access

N Jassam, N Amin, P Holland, R K Semple, D J Halsall, G Wark, and J H Barth

Background Insulin autoimmune syndrome (IAS or Hirata's disease) is a common cause of hypoglycaemia and mild insulin resistance that has most frequently been described in Japan, but is very rare within the Caucasian population (1) . In this