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Sarah Y Qian, Matthew J L Hare, Alan Pham, and Duncan J Topliss

features ( 2 ). Insulinomas classically present with fasting hypoglycaemia; however, the clinical presentation can be variable and delayed diagnosis is common. Despite considerable advances in localisation imaging, accurate surgical resection can be

Open access

S A A van den Berg and C G Krol

Background Non-islet cell tumour hypoglycaemia (NICTH) is a rare complication of malignancy. Although the exact incidence of NICTH is unknown, it is estimated to be about 1/4th of the incidence of insulinoma, but is probably underestimated

Open access

Seong Keat Cheah, David Halsall, Peter Barker, John Grant, Abraham Mathews, Shyam Seshadri, and Singhan Krishnan

/L. This was treated with bolus intravenous dextrose solution, which was then administered as continuous infusion during her inpatient stay due to recurrent hypoglycaemia. She was treated for lower respiratory tract infection, which was thought to be the

Open access

Kah-Yin Loke, Andrew Sng Anjian, Yvonne Lim Yijuan, Cindy Ho Wei Li, Maria Güemes, and Khalid Hussain

Background Hyperinsulinaemic hypoglycaemia (HH) from dysregulated insulin secretion of the pancreatic β-cells is an important cause of persistent neonatal hypoglycaemia. Mutations have been reported in the ABCC8 and KCNJ11 genes on

Open access

Ved Bhushan Arya, Jennifer Kalitsi, Ann Hickey, Sarah E Flanagan, and Ritika R Kapoor

Background Hyperinsulinaemic hypoglycaemia (HH) is the most frequent cause of severe and persistent hypoglycaemia in infants and children ( 1 ). It is characterised by inappropriate secretion of insulin in the presence of low blood glucose (BG

Open access

A Veltroni, G Zambon, S Cingarlini, and M V Davì

Background Insulin autoimmune syndrome (IAS), also known as Hirata’s disease, is a rare autoimmune disorder characterised by hyperinsulinaemic hypoglycaemia associated with high titres of antibodies to endogenous insulin, in the absence of

Open access

Sally K Abell, Jessie Teng, Anthony Dowling, Michael S Hofman, Richard J MacIsaac, and Nirupa Sachithanandan

(2) and 10–15% of insulinomas (1) may have widespread metastases at diagnosis. Symptomatic hypoglycaemia may be very difficult to control in malignant insulinoma. We report a case of recurrent inoperable metastatic pNET co-secreting both insulin

Open access

María Clemente, Alejandro Vargas, Gema Ariceta, Rosa Martínez, Ariadna Campos, and Diego Yeste

Background Hyperinsulinaemic hypoglycaemia of infancy (HHI) is the most frequent cause of persistent neonatal hypoglycaemia and hypoglycaemia in infancy and is caused by dysregulation in insulin secretion. Molecular bases are known in 50

Open access

Jennifer R Snaith, Duncan McLeod, Arthur Richardson, and David Chipps

Background Insulinomas are pancreatic neuroendocrine tumours that cause hypoglycaemia by excessive insulin secretion ( 1 ). These tumours are typically benign, solitary and surgically cured ( 2 , 3 ). Insulinomas usually occur sporadically

Open access

Ellada Sotiridou, Henrike Hoermann, Sommayya Aftab, Antonia Dastamani, Eva Thimm, Louise Doodson, Spyros Batzios, Sebastian Kummer, and Pratik Shah

, fumarylacetoacetate and succinylacetone leads to progressive liver disease, renal tubular dysfunction and porphyria-like crises ( 1 ). Hypoglycaemia is not uncommon, especially in the acute form of TT1, and could contribute to neurodevelopmental impairment observed