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Beverly T Rodrigues, Zulfiquer Otty, Kunwarjit Sangla and Vasant V Shenoy

Background This case series accentuates the importance of a high index of clinical suspicion among cancer patients on ipilimumab therapy. Although not uncommon, autoimmune hypophysitis (AH) is a relatively new clinical entity which, if left

Open access

Jaya Sujatha Gopal-Kothandapani, Veejay Bagga, Stephen B Wharton, Daniel J Connolly, Saurabh Sinha and Paul J Dimitri

Background Pituitary hypophysitis is a rare, inflammatory condition that may present both clinically and radiologically as a neoplastic lesion (1) . Clinically, it is associated with headaches and visual disturbance due to the local mass

Open access

Marlene Tarvainen, Satu Mäkelä, Jukka Mustonen and Pia Jaatinen

hypophysitis six to twelve months after the acute NE. We also review previous case reports on HFRS-induced hypopituitarism. Case presentation A 25-year-old previously healthy woman presented with fever of 39°C, oliguria and lower back pain. At

Open access

Isabella Lupi, Alessandro Brancatella, Mirco Cosottini, Nicola Viola, Giulia Lanzolla, Daniele Sgrò, Giulia Di Dalmazi, Francesco Latrofa, Patrizio Caturegli and Claudio Marcocci

sites such as skin, intestine, liver, lungs, and endocrine glands are preferentially targeted ( 2 ). Hypophysitis caused by ICIs is seen most commonly in cancer patients treated with ipilimumab (anti-CTLA4) where it has a prevalence of about 12% ( 3

Open access

Takatoshi Anno, Fumiko Kawasaki, Maiko Takai, Ryo Shigemoto, Yuki Kan, Hideaki Kaneto, Tomoatsu Mune, Kohei Kaku and Niro Okimoto

Background IgG4-related disease is a multi- or single-organ disorder accompanied by the increase of serum IgG4 level ( 1 ). Recently, clinical characteristics of IgG4-related hypophysitis have emerged as a part of systemic IgG4-related disease

Open access

Gabriela Alejandra Sosa, Soledad Bell, Silvia Beatriz Christiansen, Marcelo Pietrani, Mariela Glerean, Monica Loto, Soledad Lovazzano, Antonio Carrizo, Pablo Ajler and Patricia Fainstein Day

Background Hypophysitis is a rare entity characterised by chronic inflammation of the pituitary, and is classified as primary and secondary based on its aetiology. Secondary hypophysitis includes cases resulting from other sellar lesions

Open access

Danielle R Bullock, Bradley S Miller, H Brent Clark and Patricia M Hobday

system, some refer to it as analogous to sarcoidosis: a systemic disease affecting variable organs but with the same pathologic features ( 1 ). IgG4-related hypophysitis, a specific manifestation of IgG4-related disease, was described as early as 2004

Open access

Rayna Patel, Waheed Mustafa, Michael T Sheaff and Sami Khan

lymphocytic hypophysitis. The patient’s chest pain resolved with analgesia, and he was discharged for outpatient follow-up. Figure 2 MRI pituitary with contrast demonstrated a thickened pituitary infundibulum (3.7mm craniocaudal and 4.9mm transverse) with

Open access

Shunsuke Funazaki, Hodaka Yamada, Kazuo Hara and San-e Ishikawa

Background Lymphocytic hypophysitis (LyH) is an autoimmune disorder characterized by lymphocyte infiltration into the pituitary gland and induction of chronic inflammation, leading to pituitary dysfunction. Its onset has been linked to

Open access

H Joshi, M Hikmat, A P Devadass, S O Oyibo and S V Sagi

on adjunct immunosuppressive agents for relapsing cases. Although IgG4-RD is a multi-systemic disorder, there have been cases of isolated IgG4-related hypophysitis ( 3 ). Affected patients usually present with features of anterior and/or posterior