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M Nwokolo and J Fletcher

10 and 5 mg daily and she remains under 12-month follow-up. Discussion We report a case of hypopituitarism presenting as acute adrenal failure with frank psychosis and empty sella turcica. As symptoms originally developed post partum on a

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Charlotte Delcourt, Halil Yildiz, Alessandra Camboni, Eric Van den Neste, Véronique Roelants, Alexandra Kozyreff, Jean Paul Thissen, Dominique Maiter and Raluca Maria Furnica

and no clinically palpable lymph node. She did not present any polyuria-polydipsia syndrome, nor had any biological sign of diabetes insipidus. The hormonal profile confirmed anterior hypopituitarism with deficiencies of the thyreotrope, corticotrope

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Misaki Aoshima, Koji Nagayama, Kei Takeshita, Hiroshi Ajima, Sakurako Orikasa, Ayana Iwazaki, Hiroaki Takatori and Yutaka Oki

, luteinizing hormone; TSH, thyroid-stimulating hormone. Further endocrine examination showed hypopituitarism, without growth hormone (GH) deficiency. A hypotonic saline infusion test and DDAVP test confirmed the diagnosis of central diabetes insipidus

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Carlos Tavares Bello, Francisco Sousa Santos, João Sequeira Duarte and Carlos Vasconcelos

after the second birth, despite preservation of regular menses. No headaches, visual field defects or any other clinical or laboratory suggestions of hypopituitarism were present. Before hospital admission, the patient described polyuria (allegedly

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Siew Hui Foo and Shahada A H Sobah

Background Hypopituitarism is a rare presentation of Burkitt's lymphoma (BL), a highly aggressive type of B-cell non-Hodgkin's lymphoma (NHL) associated with rapid and aggressive clinical course (1) . The diagnosis of BL is considered a

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Carlos Tavares Bello, Patricia Cipriano, Vanessa Henriques, João Sequeira Duarte and Conceição Canas Marques

endocrine changes in approximately 50%: amenorrhea, galactorrhea, infertility, impotence and weight fluctuations ( 4 ). Signs of hypopituitarism or hyperprolactinaemia are the most frequent findings; however, a case report of acromegaly has been described in

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Shunsuke Funazaki, Hodaka Yamada, Kazuo Hara and San-e Ishikawa

gestation or the postpartum period in most females. Despite prednisolone treatment, the disorder may remain persistent and result in hypopituitarism. Accordingly, only a few reports have indicated curable cases of LyH. The present study details our

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H Joshi, M Hikmat, A P Devadass, S O Oyibo and S V Sagi

hypopituitarism. We present a patient with IgG4-related hypophysitis resulting in anterior hypopituitarism. Case presentation A 39-year-old man of Asian origin, presented with a 4-week history of frontal headache and recent onset double vision. He was

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Nicholas J Theis, Toby Calvert, Peter McIntyre, Stephen P Robertson and Benjamin J Wheeler

Summary

Cantu syndrome, or hypertrichotic osteochondrodysplasia, is a rare, autosomal dominant genetically heterogeneous disorder. It is characterized by hypertrichosis, cardiac and skeletal anomalies and distinctive coarse facial features. We report a case where slowed growth velocity at 13 years led to identification of multiple pituitary hormone deficiencies. This adds to other reports of pituitary abnormalities in this condition and supports inclusion of endocrine monitoring in the clinical surveillance of patients with Cantu syndrome.

Learning points:

  • Cantu syndrome is a rare genetic disorder caused by pathogenic variants in the ABCC9 and KCNJ8 genes, which result in gain of function of the SUR2 or Kir6.1 subunits of widely expressed KATP channels.
  • The main manifestations of the syndrome are varied, but most commonly include hypertrichosis, macrosomia, macrocephaly, coarse ‘acromegaloid’ facies, and a range of cardiac defects.
  • Anterior pituitary dysfunction may be implicated in this disorder, and we propose that routine screening should be included in the clinical and biochemical surveillance of patients with Cantu syndrome.
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Jordan Yardain Amar, Kimberly Borden, Elizabeth Watson and Talin Arslanian

; T1, treatment year 1; T2, treatment year 2. Discussion This case highlights a rare cause of primary hypopituitarism with a broad differential diagnosis. Idiopathic Short Stature was considered as a possible cause, but was unlikely as