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Tess Jacob, Renee Garrick and Michael D Goldberg

Background Metformin is currently recommended by many professional organizations as the first-line agent for the treatment of type 2 diabetes ( 1 ). Its multiple advantages include potent glucose-lowering efficacy, absence of weight gain

Open access

Murray B Gordon and Kellie L Spiller

-hour 5-point mean GH: 1.7 ng/mL), which led to the acromegaly diagnosis. The patient also had an elevated baseline level of FPG (140 mg/dL) and HbA 1c (7.5%) and was being treated with metformin 1000 mg twice daily (b.i.d.), pioglitazone 45 mg once

Open access

Peter Novodvorsky, Emma Walkinshaw, Waliur Rahman, Valerie Gordon, Karen Towse, Sarah Mitchell, Dinesh Selvarajah, Priya Madhuvrata and Alia Munir

) values were diagnostic of GDM ( 6 ) ( Table 1A ) and metformin was started at 15/40. BM values continued to be elevated on metformin ( Table 1B ), and insulin (Humulin I and Humalog (Eli Lilly)) was added 2 weeks later. Table 1 Example of capillary

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Athanasios Fountas, Zoe Giotaki, Evangelia Dounousi, George Liapis, Alexandra Bargiota, Agathocles Tsatsoulis and Stelios Tigas

cardiomyopathy ( 10 ), the patient underwent a transthoracic echocardiography and electrocardiography, which did not reveal any pathological findings. The patient was initially treated with metformin and later with pioglitazone and atorvastatin and follow

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Clarissa Ern Hui Fang, Mohammed Faraz Rafey, Aine Cunningham, Sean F Dinneen and Francis M Finucane

daily insulin dose from 35 to 18 units and added metformin 500 mg twice daily, increasing to 1000 mg 2 weeks later and gradually titrating his insulin dose to zero, 7 weeks after his initial presentation. At 6 months, his BMI, glucometer readings, HbA1c

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Ken Takeshima, Hiroyuki Ariyasu, Tatsuya Ishibashi, Shintaro Kawai, Shinsuke Uraki, Jinsoo Koh, Hidefumi Ito and Takashi Akamizu

remained uncertain. Glycemic control deteriorated over three years, with HbA1c from 7.0% to 9.4%. On admission, he was treated with 39 units of insulin aspart, sitagliptin 50 mg, voglibose 0.6 mg and metformin 1000 mg per day. The patient was suspected of

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Jiman Kim, Eulsun Moon and Seungwon Kwon

January 2012 because of several hypoglycemic events and oral hypoglycemic therapy was resumed (sitagliptin 100 mg/day, metformin 500 mg/day). However, in November 2013, diabetic nephropathy corresponding to stage 3 chronic kidney disease (CKD) was detected

Open access

E Rapti, S Karras, M Grammatiki, A Mousiolis, X Tsekmekidou, E Potolidis, P Zebekakis, M Daniilidis and K Kotsa

patient declined insulin therapy and was initially treated with gliclazide once daily and metformin 1000mg twice daily with the suggestion of regular consultation in an outpatient diabetes clinic. On presentation to the diabetes outpatient setting 3

Open access

Michelle Maher, Mohammed Faraz Rafey, Helena Griffin, Katie Cunningham and Francis M Finucane

taking metformin 500 mg three times daily, ramipril 2.5 mg once daily, simvastatin 30 mg once daily and aspirin 75 mg once daily. He did not drink alcohol and had stopped smoking 6 months previously with a 26 pack year history. His mother and sister had T

Open access

Ahmad Haider, Karim S Haider and Farid Saad

of referral, the obese patient (BMI: 37.1 kg/m 2 ) had T2DM for 4 years, was on metformin for the same period and, in addition, on insulin treatment for 2 years at 22 IU per day. Under insulin, the patient had gained 5 kg. Doctors’ instructions to