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Manas Ghosh, Ambarish Bhattacharya, Kaushik Ghosh, Atri Chatterjee, Sisir Chakraborty, and Sanat Kumar Jatua

spinal muscle atrophy and amyotrophic lateral sclerosis (ALS). ALS is the most common form of motor neuron disease (MND). Till date, there has been no curative therapy for this neurodegenerative disease. Although there have been some reports suggesting

Open access

A Pazderska, S Crowther, P Govender, K C Conlon, M Sherlock, and J Gibney

opinion was sought. The patient reported weight gain, secondary amenorrhoea of 2year duration and a recent onset of facial hirsutism. On examination, she had abdominal adiposity with violaceous striae, facial plethora and hirsutism, atrophic skin, multiple

Open access

S F Wan Muhammad Hatta, L Kandaswamy, C Gherman-Ciolac, J Mann, and H N Buch

mechanisms. It can interfere with insulin-like growth factor-1 (IGF-1) signalling, leading to increased myocyte apoptosis ( 6 ), which leads to myopathy and muscle atrophy. An intracellular signalling molecule with protein kinase activity known as Akt 1 may

Open access

Carlos Tavares Bello, Patricia Cipriano, Vanessa Henriques, João Sequeira Duarte, and Conceição Canas Marques

department with nausea, vomiting and slightly decreased visual acuity. Clinical examination was remarkable for decreased facial and body hair, slight muscle atrophy without any other features suggestive of pituitary dysfunction namely hypotension, polyuria

Open access

Harish Venugopal, Katherine Griffin, and Saima Amer

evaluation and management. Case presentation A 66-year-old gentleman was admitted under our care with a 6-month history of rapidly declining mobility with severe proximal muscle weakness and atrophy affecting both lower and upper limbs. A recent

Open access

N Siddique, R Durcan, S Smyth, T Kyaw Tun, S Sreenan, and J H McDermott

weakness, such that he walked with a stick. He had lost a further 3 kg in weight despite good glycaemic control. Examination revealed weakness of left hip flexion and left knee extension, an absent left patellar reflex and an atrophied left quadriceps. HbA1

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Teresa Rego, Fernando Fonseca, Stéphanie Espiard, Karine Perlemoine, Jérôme Bertherat, and Ana Agapito

, obesity (BMI 30 kg/m 2 ) with centripetal fat distribution and major muscle atrophy of the limbs. Familial medical history She had an apparently healthy 46-year-old son. Her 47-year-old daughter had been treated by one of the authors in 2006 for

Open access

Julien Ducry, Fulgencio Gomez, John O Prior, Ariane Boubaker, Maurice Matter, Matteo Monti, Yan Pu, Nelly Pitteloud, and Luc Portmann

but hemodynamically stable without respiratory insufficiency. He showed slight facial redness, marked proximal limb muscles atrophy, and mild skin thinning with bruises. There was no moon face, purple striae, supra-clavicular fat pads, or buffalo hump

Open access

Ken Takeshima, Hiroyuki Ariyasu, Tatsuya Ishibashi, Shintaro Kawai, Shinsuke Uraki, Jinsoo Koh, Hidefumi Ito, and Takashi Akamizu

; NGSP, National Glycohemoglobin Standardization Program. The patient had thin, sharp, so-called ‘hatchet’ facial features ( Fig. 1A ). Upper and lower extremities were thin with muscle atrophy. He had mild weakness in bilateral facial muscles

Open access

Lourdes Balcázar-Hernández, Guadalupe Vargas-Ortega, Yelitza Valverde-García, Victoria Mendoza-Zubieta, and Baldomero González-Virla

, nutritional supervision was continued; however, loss of weight, anorexia, limitations of activities of daily living, weakness, muscle atrophy, anhedonia and abulia persisted. Multiple strategies were developed for enteral feeding. The diagnosis of anorexia