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S A A van den Berg and C G Krol

Background Non-islet cell tumour hypoglycaemia (NICTH) is a rare complication of malignancy. Although the exact incidence of NICTH is unknown, it is estimated to be about 1/4th of the incidence of insulinoma, but is probably underestimated

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G K Dimitriadis, K Gopalakrishnan, R Rao, D K Grammatopoulos, H S Randeva, M O Weickert and N Murthy

occasionally occur in non-islet cell tumours. Non islet cell tumour hypoglycemia (NICTH) is observed in some epithelial and mesenchymal tumours and rarely also in GISTs. NICTH is characterised by recurrent fasting hypoglycaemia and associated with the

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Kamel Mohammedi, Charbel Abi Khalil, Sophie Olivier, Imane Benabad, Ronan Roussel and Michel Marre

-II-producing solitary fibrous tumor . Internal Medicine . 45 : 525 – 529 . ( doi:10.2169/internalmedicine.45.1611 ) Teale JD Wark G 2004 The effectiveness of different treatment options for non-islet cell tumour hypoglycaemia . Clinical

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Katia Regina Marchetti, Maria Adelaide Albergaria Pereira, Arnaldo Lichtenstein and Edison Ferreira Paiva

1998 Glucocorticosteroid therapy suppresses abnormal secretion of big IGF-II by non-islet cell tumours inducing hypoglycaemia . Clinical Endocrinology 49 491 – 498 . ( doi:10.1046/j.1365-2265.1998.00564.x ) 9 Teale JD Wark G 2004 The

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Seong Keat Cheah, David Halsall, Peter Barker, John Grant, Abraham Mathews, Shyam Seshadri and Singhan Krishnan

) and liver lesions (black arrows) (C). In view of the renal lesion, non-islet cell tumour-induced hypoglycaemia (NICTH) was suspected as this has been reported in cases of renal malignancies ( 5 , 6 ). However, the IGF2:IGF1 ratio was

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Noman Ahmad, Abdulmonem Mohammed Almutawa, Mohamed Ziyad Abubacker, Hossam Ahmed Elzeftawy and Osama Abdullah Bawazir

hyperinsulinism is the most common cause of hyperinsulinaemic hypoglycaemia in infancy. Hypoglycaemia beyond the age of infancy can be due to an insulinoma or beta islet cell tumour of pancreas. Insulinoma is a very rare tumour, and its incidence in children is

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S Solomou, R Khan, D Propper, D Berney and M Druce

the islets of Langerhans, which produce excess insulin and C-peptide. Insulinomas are rare, with their incidence being estimated to be four per one million person-years (1) . Non-islet-cell tumour hypoglycaemia also occurs, most commonly due to

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Benjamin G Challis, Nicolai J Wewer Albrechtsen, Vishakha Bansiya, Keith Burling, Peter Barker, Bolette Hartmann, Fiona Gribble, Stephen O'Rahilly, Jens J Holst and Helen L Simpson

islet cell tumour co-secreting insulin and glucagon. A supervised fast with concomitant measurement of additional gut hormones ( Table 1 ) was undertaken. Hyperinsulinaemic hypoglycaemia (blood glucose 1.7 mmol/l, insulin 143 pM (NR: 0–60) and proinsulin

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Kah-Yin Loke, Andrew Sng Anjian, Yvonne Lim Yijuan, Cindy Ho Wei Li, Maria Güemes and Khalid Hussain

Background Hyperinsulinaemic hypoglycaemia (HH) from dysregulated insulin secretion of the pancreatic β-cells is an important cause of persistent neonatal hypoglycaemia. Mutations have been reported in the ABCC8 and KCNJ11 genes on

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Suresh Chandran, Fabian Yap Kok Peng, Victor Samuel Rajadurai, Yap Te Lu, Kenneth T E Chang, S E Flanagan, S Ellard and Khalid Hussain

( Fig. 1 Bi) to large ( Fig. 1 Bii) islets. The islets showed scattered endocrine cells with large and hyperchromatic nuclei ( Fig. 1 Bi and ii). These changes are consistent with typical diffuse disease. Owing to the persistent hypoglycaemia, he