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Mads Ryø Jochumsen, Peter Iversen, and Anne Kirstine Arveschoug

cancer. 11-C-Met PET might have a role as a novel diagnostic procedure in thyroid cancer and in qualifying whether cold thyroid nodules with Sestamibi uptake are suspicious of malignancy or not. Case presentation A 66-year-old woman with a known

Open access

Nami Mohammadian Khonsari, Benyamin Hakak-Zargar, Tessa Voth, and Shahab Noorian

of ichthyosis and global developmental delay. In our opinion, this can be a very useful indicator to identify the condition and can be the best diagnostic sign of the disease in infancy. Our patient had typical features of infantile MSD, including

Open access

Deep Dutta, Chitra Selvan, Manoj Kumar, Saumik Datta, Ram Narayan Das, Sujoy Ghosh, Satinath Mukhopadhyay, and Subhankar Chowdhury

setting of inconclusive neck USG and Tc 99m sestamibi imaging (8) . FNA-iPTH is considered positive and diagnostic of parathyroid adenoma if FNA-iPTH level is higher than serum iPTH of the patient (9) . FNA-iPTH was negative in our patient. However

Open access

Betty Korljan Jelaska, Sanja Baršić Ostojić, Nina Berović, and Višnja Kokić

hyperuricaemia. She came to our clinic at the age of 22 years for the diagnostic evaluation of arterial hypertension and dyslipidaemia. Her weight was initially 80 kg, height was 157 cm and BMI was 32.5. The levels of uric acid were 425 nmol/l, LDL 3 mmol/l, HDL

Open access

Thien Vinh Luong, Lars Rejnmark, Anne Kirstine Arveschoug, Peter Iversen, and Lars Rolighed

biopsy and future localization. Figure 5 An enlarged right thymus was removed during the procedure with the suspicion of containing an ectopic parathyroid gland. However, no parathyroid tissue was revealed in the histologic examination

Open access

E Bahaeldein and M J Brassill

diagnostic tool to help confirm an ovarian source of androgen excess. Available algorithms have recommended combined adrenal and ovarian venous sampling if imaging is inconclusive ( 3 , 4 ). This procedure is technically difficult however, and requires an

Open access

N F Lenders and J R Greenfield

approximately 160 cases reported in the literature ( 2 ). Differentiating between adrenal tumour types poses a significant diagnostic challenge. Serum biochemistry determines the presence of adrenal hormone excess. Distinguishing between benign and malignant

Open access

S Vimalesvaran, S Narayanaswamy, L Yang, J K Prague, A Buckley, A D Miras, S Franks, K Meeran, and W S Dhillo

amenorrhoea. PCOS is the commonest endocrine condition in women of reproductive age and affects approximately 6–8% of this age group ( 3 ). It remains a complex and heterogeneous condition. The three main diagnostic classification systems at present are the

Open access

Nishant Raizada, S H Rahaman, D Kandasamy, and V P Jyotsna


Insulin autoimmune syndrome (IAS) is a rare cause of hyperinsulinemic hypoglycaemia, which is known to occur in association with the use of sulfhydryl-containing drugs and autoimmune disorders. We describe a patient with hitherto an unreported association of IAS with ankylosing spondylitis. We have also performed and described a simplified method of polyethylene glycol (PEG) precipitation of an insulin bound antibody in the serum.

Learning points

  • IAS should be considered in differential diagnosis of endogenous hyperinsulinemic hypoglycaemia.
  • Ankylosing spondylitis can be associated with IAS apart from several other autoimmune diseases.
  • Very high serum insulin levels (100–10 000 μU/ml) are frequently seen in IAS.
  • When faced with very high serum insulin before suspecting insulinoma, it is advisable that PEG precipitation of serum be done to identify antibody bound insulin.
  • A clinical suspicion of IAS can avoid expensive imaging and unnecessary surgery in affected patients.

Open access

Huanyu Ding, Yang Li, Caishun Ruan, Yuan Gao, Hehua Wang, Xiangsong Zhang, and Zhihong Liao

secondary to familial thrombocytopenia and Hashimoto's thyroiditis. The case we reported here did not meet the diagnostic criteria of IgG4 related diseases because IgG4 to IgG ratio was lower than 40% and serum IgG4 level was within normal range. But we