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Takuma Hara, Hiroyoshi Akutsu, Tetsuya Yamamoto, Eiichi Ishikawa, Masahide Matsuda, and Akira Matsumura

Background Cushing's disease accounts for 4.7% of pituitary adenomas (1) , and typically patients show clinical symptoms of impaired glucose tolerance, hypertension, central obesity, moon face, osteoporosis, and psychosis (2) (3) . Gastric

Open access

Roberto Salvatori, Adrian F Daly, Alfredo Quinones-Hinojosa, Albert Thiry, and Albert Beckers

Background Germline inactivating mutations in the aryl hydrocarbon receptor-interacting protein ( AIP ) gene lead to pituitary adenomas that most frequently present in the setting of familial isolated pituitary adenoma (FIPA) syndrome, usually

Open access

Yoko Olmedilla, Shoaib Khan, Victoria Young, Robin Joseph, Simon Cudlip, Olaf Ansgorge, Ashley Grossman, and Aparna Pal

hypersecretion and associated clinical features may not necessarily align. Furthermore, bacterial meningitis as first presentation of a pituitary adenoma is also highly uncommon ( 3 ). Although transsphenoidal adenomectomy is still considered the first

Open access

Sharmin Jahan, M A Hasanat, Tahseen Mahmood, Shahed Morshed, Raziul Haq, and Md Fariduddin

nonfunctioning pituitary macroadenoma. There was no family history suggestive of any pituitary tumor or genetic syndrome associated with adrenal tumor. Following that he underwent trans-sphenoidal adenomectomy (TSA) and post-surgical histopathology revealed

Open access

Runa Acharya and Udaya M Kabadi

of Cushing’s disease secondary to ACTH-producing pituitary adenoma. Case presentation A 48-year-old Caucasian woman was admitted with fever, cough, left-sided chest pain, shortness of breath and hemoptysis. She reported amenorrhea of one

Open access

Hui Yi Ng, Divya Namboodiri, Diana Learoyd, Andrew Davidson, Bernard Champion, and Veronica Preda

Background Less than 1% of pituitary adenomas are thyrotropinomas, secreting thyroid-stimulating hormone (TSH), about 30% co-secrete growth hormone (GH), prolactin (PRL) and αGSU of thyroid-stimulating hormone (TSH) ( 1 ). They are pit-1

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I R Wallace, E Healy, R S Cooke, P K Ellis, R Harper, and S J Hunter

inhibition following T 3 administered as a suppression test (1) . Management of TSH-secreting pituitary adenomas is principally via surgical adenomectomy. Postoperative external irradiation is a frequent adjunctive therapy (1) . Somatostatin analogues

Open access

Emilia Sbardella, George Farah, Ahmed Fathelrahman, Simon Cudlip, Olaf Ansorge, Niki Karavitaki, and Ashley B Grossman

Background Pituitary tumours are a relatively common intracranial neoplasm. Approximately 10–20% of the normal population may harbour these lesions according to autopsy and/or pituitary magnetic resonance imaging (MRI) series: most of these

Open access

Eline van der Valk, Tom Tobe, Aline Stades, and Alex Muller

) Takamoto S Tsuchiya H Onishi T Morimoto S Imanaka S Mori S Seino Y Uozumi T Kumahara Y 1985 Changes in calcium homeostasis in acromegaly treated by pituitary adenomectomy . Journal

Open access

Nyasatu G Chamba, Ahlam A Amour, Abid M Sadiq, Tecla R Lyamuya, Emmanuel V Assey, Adnan M Sadiq, and William P Howlett

Background Acromegaly is a rare clinical condition resulting from excessive secretion of growth hormone (GH), which stimulates excessive production of insulin-like growth factor type 1 (IGF-1). Most cases are caused by a GH secreting pituitary