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Open access

Ilse C A Bakker, Chris D Schubart and Pierre M J Zelissen

Background Prolactinomas are among the most frequently occurring pituitary adenomas. The vast majority of these adenomas respond favourably to medical therapy with dopaminergic drugs leading to normoprolactinaemia and regression of adenoma

Open access

Wael M Almistehi and Mussa H Almalki

Background Pituitary tumors account for 10–15% of all intracranial tumors. Prolactinomas are the most frequently occurring pituitary tumors with a prevalence of 3.5–5 per 10 000 inhabitants, according to recent epidemiological studies ( 1 , 2

Open access

Ekaterina Manuylova, Laura M Calvi, Catherine Hastings, G Edward Vates, Mahlon D Johnson, William T Cave Jr and Ismat Shafiq

prevalence of GH secretion among prolactinomas is unknown but thought to be rare. The current literature emphasizes screening for GH excess by checking insulin-like growth factor 1 (IGF-1) in patients with prolactinoma at the time of the initial diagnosis

Open access

Niki Margari, Jonathan Pollock and Nemanja Stojanovic

Background We describe the case of a female patient who presented with ophthalmoplegia and subsequent pituitary profile and her image revealed a giant invasive prolactinoma compressing the brainstem. It was initially managed with dopamine

Open access

L I Astaf’eva, Y G Sidneva, B A Kadashev, P L Kalinin, G A Melnichenko and S A Agadzhanian

Background Giant prolactinomas are a rare entity; they are mainly found in men, are locally aggressive, invading the cavernous sinuses and skull base bones, and extending to the nasal cavity, paranasal sinuses and nasopharynx ( 1 , 2 ). Giant

Open access

J Bukowczan, K Lois, M Mathiopoulou, A B Grossman and R A James

Background Reversible cognitive impairment associated with the treatment of a prolactin-secreting pituitary adenoma has not been previously described. Herein we report the first case of an invasive giant prolactinoma causing a profound decline

Open access

J K Prague, C L Ward, O G Mustafa, B C Whitelaw, A King, N W Thomas and J Gilbert

Background Prolactinomas are the most common subtype of pituitary tumours (57%), occurring particularly in women (1) . However, giant prolactinomas are very rare tumours (4% of all prolactinomas in one series) (2) , and have a significant

Open access

Ellena Cotton and David Ray

Background Prolactinomas are the most common type of pituitary tumour. Most prolactinomas are sporadic, but genetic syndromes increase risk. The aim of this report is to present a female patient, carrying a DICER1 mutation, who developed a

Open access

Maryam Rahman, Ignacio Jusué-Torres, Abdulrahman Alkabbani, Roberto Salvatori, Fausto J Rodríguez and Alfredo Quinones-Hinojosa

adenoma. However, previous reports have described the rare occurrence of synchronous GH- and prolactin-secreting adenomas. We present a case of synchronous occurrence of a prolactinoma and somatotropinoma. Case presentation A woman presented to an

Open access

Niki Margari and Simon Page

profiling, a diagnosis of bacterial meningitis secondary to invading prolactinoma was made. Treatment The patient was commenced on i.v. ceftriaxone 2 g once daily and amoxicillin 2 g every 4 h for 2 weeks to treat the pneumococcal meningitis. The