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Nicola Tufton, Nazhri Hashim, Candy Sze, and Mona Waterhouse

identification and prompt initiation of treatment are needed to minimise complications and prevent the mortality associated with this condition. Propylthiouracil (PTU) was the preferred treatment for thyroid storm due to its properties of inhibiting peripheral

Open access

Maria Tomkins, Roxana Maria Tudor, Diarmuid Smith, and Amar Agha

Background This case report describes a patient who experienced concomitant agranulocytosis and anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis as an adverse effect of propylthiouracil treatment for Graves’ disease

Open access

Fernando Gomez-Peralta, Pablo Velasco-Martínez, Cristina Abreu, María Cepeda, and Marta Fernández-Puente

focus on the most widely used drugs, the rate of liver dysfunction, including mild elevation of transaminase, rise by 15% ( 1 , 2 ). These common ATDs are methimazole (MMI) and propylthiouracil (PTU). Despite their relatively safe profiles, both can

Open access

Han Soo Park, Su Kyoung Kwon, and Ye Na Kim

conventional medical treatment for thyroid storm (oral propylthiouracil, Lugol solution, intravenous beta-blocker and steroids) after emergent cardiac resuscitation and was given general supportive management (intravenous propacetamol, hydration, antibiotics

Open access

Carolina Shalini Singarayar, Foo Siew Hui, Nicholas Cheong, and Goay Swee En

to suggest an underlying connective tissue disease, chronic pulmonary or thromboembolic disorders. She was diagnosed with acute appendicitis with impending thyroid storm. High-dose propylthiouracil, propranolol, Lugol’s iodine and hydrocortisone were

Open access

Anastasia Dimakopoulou, Karunakaran Vithian, David Gannon, and Allan Harkness

impaired with an ejection fraction of 30–35% ( Fig. 2 ). Figure 2 Takotsubo cardiomyopathy on echocardiogram – parasternal long axis on original presentation. Outcome and follow-up Our patient was treated with propylthiouracil

Open access

Ling Zhu, Sueziani Binte Zainudin, Manish Kaushik, Li Yan Khor, and Chiaw Ling Chng

of the thyroid uptake scan and TSH receptor antibody titre. Treatment He was initially treated with oral propranolol 20mg every 8h, intravenous hydrocortisone 100mg every 6h, intravenous digoxin 500μg once, oral propylthiouracil 400mg once

Open access

J K Witczak, N Ubaysekara, R Ravindran, S Rice, Z Yousef, and L D Premawardhana

). Subject 3 She was commenced on bisoprolol 10 mg OD, digoxin 125 µg OD, propylthiouracil 100 mg BD (carbimazole intolerant – rash), furosemide 40 mg OD and ramipril 1.25 mg OD. We decided not to anticoagulate her in view of a microcytic anaemia and severe

Open access

Yuri Tanaka, Taisuke Uchida, Hideki Yamaguchi, Yohei Kudo, Tadato Yonekawa, and Masamitsu Nakazato

. Outcome and follow-up Transaminase levels decreased, but levels of total bilirubin increased and prothrombin time became prolonged ( Fig. 2 ). The switch from methimazole to propylthiouracil was not effective. CT of the abdomen showed increased ascites

Open access

Serena Khoo, Greta Lyons, Andrew Solomon, Susan Oddy, David Halsall, Krishna Chatterjee, and Carla Moran

thyroxine and propylthiouracil (PTU) treatment indicated. Reference ranges for FT4 (shaded light grey) and TSH (shaded dark grey) are marked. TED: Thyroid eye disease. In October 2016, she developed excessive lacrimation, exposure symptoms and