of hypothyroidism of 24.2% in a sample of 400 postmenopausal women in Puerto Rico ( 1 ). Levothyroxine must be taken on an empty stomach for adequate absorption in the small intestine. This may compromise adherence to therapy in some patients who
Andrea del Toro-Diez, Ernesto Solá-Sánchez, and Michelle Mangual-García
Nicolás Cruz-Dardíz, Nadyeschka Rivera-Santana, Marina Torres-Torres, Héctor Cintrón-Colón, Shayanne Lajud, Ernesto Solá-Sánchez, Michelle Mangual-García, and Alex González-Bóssolo
Lingual thyroid (LT) gland is the most common type of ectopic thyroid tissue, but it is an extremely rare presentation. We present a case of a 41-year-old Hispanic female patient complaining of dysphonia and dysphagia. As part of the evaluation, fiber optic flexible indirect laryngoscopy (FIL) was performed which revealed a mass at the base of the tongue. The morphological examination was highly suspicious for ectopic thyroid tissue and the diagnosis was confirmed with neck ultrasound and thyroid scintigraphy. Although the patient presented subclinical hypothyroidism, levothyroxine therapy was initiated with a favorable response which included resolution of symptoms and mass size reduction. Our case portrays how thyroid hormone replacement therapy (THRT) may lead to a reduction in the size of the ectopic tissue and improvement of symptoms, thus avoiding the need for surgical intervention which could result in profound hypothyroidism severely affecting the patients’ quality of life.
Benign LT and malignant LT are indistinguishable clinically and radiographically for which histopathology is recommended.
THRT, radioactive iodine 131 (RAI) therapy, and surgical excision are potential management options for LT.
THRT may lead to size reduction of the ectopic tissue and resolution of symptoms avoiding surgical intervention.
Ernesto Solá, Carmen Rivera, Michelle Mangual, José Martinez, Kelvin Rivera, and Ricardo Fernandez
Diabetes mellitus was identified as a risk factor for developing tuberculosis (TB) infection, and relapse after therapy. The risk of acquiring TB is described as comparable to that of HIV population. The fact that diabetics are 3× times more prone to develop pulmonary TB than nondiabetics cannot be overlooked. With DM recognized as global epidemic, and TB affecting one-third of the world population, physicians must remain vigilant. We present a 45-year-old woman born in Dominican Republic (DR), with 10-year history of T2DM treated with metformin, arrived to our Urgency Room complaining of dry cough for the past 3months. Interview unveiled unintentional 15lbs weight loss, night sweats, occasional unquantified fever, and general malaise but denied bloody sputum. She traveled to DR 2years before, with no known ill exposure. Physical examination showed a thin body habitus, otherwise well appearing woman with stable vital signs, presenting solely right middle lung field ronchi. LDH, ESR, hsCRP and Hg A1C were elevated. Imaging revealed a right middle lobe cavitation. Sputum for AFB disclosed active pulmonary TB. Our case portrays that the consideration of TB as differential diagnosis in diabetics should be exercised with the same strength, as it is undertaken during the evaluation of HIV patients with lung cavitation. Inability to recognize TB will endanger the patient, hospital dwellers and staff, and perpetuate this global public health menace.
Diabetes mellitus should be considered an important risk factor for the reactivation of pulmonary tuberculosis.
High clinical suspicious should be taken into consideration as radiological findings for pulmonary tuberculosis in patients with diabetes mellitus may be atypical, involving middle and lower lobes.
Inability to recognize pulmonary tuberculosis will endanger the patient, hospital dwellers and staff, and perpetuate this global public health menace.
Alex González Bóssolo, Michelle Mangual Garcia, Paula Jeffs González, Miosotis Garcia, Guillermo Villarmarzo, and Jose Hernán Martinez
Classical papillary thyroid microcarcinoma (PTMC) is a variant of papillary thyroid carcinoma (PTC) known to have excellent prognosis. It has a mortality of 0.3%, even in the presence of distance metastasis. The latest American Thyroid Association guidelines state that although lobectomy is acceptable, active surveillance can be considered in the appropriate setting. We present the case of a 37-year-old female with a history of PTMC who underwent surgical management consisting of a total thyroidectomy. Although she has remained disease-free, her quality of life has been greatly affected by the sequelae of this procedure. This case serves as an excellent example of how first-line surgical treatment may result more harmful than the disease itself.
Papillary thyroid microcarcinoma (PTMC) has an excellent prognosis with a mortality of less than 1% even with the presence of distant metastases.
Active surveillance is a reasonable management approach for appropriately selected patients.
Patients should be thoroughly oriented about the risks and benefits of active surveillance vs immediate surgical treatment. This discussion should include the sequelae of surgery and potential impact on quality of life, especially in the younger population.
More studies are needed for stratification of PTMC behavior to determine if conservative management is adequate for all patients with this specific disease variant.
Vivienne Yoon, Aliya Heyliger, Takashi Maekawa, Hironobu Sasano, Kelley Carrick, Stacey Woodruff, Jennifer Rabaglia, Richard J Auchus, and Hans K Ghayee
report . Puerto Rico Health Sciences Journal . 29 : 130 – 132 . 20496530 Piaditis GP Kaltsas GA Androulakis II Gouli A Makras P Papadogias D Dimitriou K Ragkou D Markou A