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Joseph A Chorny, John J Orrego, and José Manuel Cameselle-Teijeiro

was nonreactive with Congo red and thioflavin T stains (B, H&E, 400×). The tumor cells were immunoreactive for synaptophysin (C, 200×). No calcitonin mRNA was detected by in situ hybridization; positivity was found in a case of C-cell hyperplasia

Open access

Bernardo Marques, Raquel G Martins, Guilherme Tralhão, Joana Couto, Sandra Saraiva, Henrique Ferrão, João Ribeiro, Jacinta Santos, Teresa Martins, Ana Teresa Cadime, and Fernando Rodrigues

hepatic lesions (Ki67 = 5%), with positive staining for chromogranin and synaptophysin. The histological report on the stomach revealed mild glandular atrophy, but no areas of intestinal metaplasia or inflammation of the lamina propria and no evidence of

Open access

J Pedro, F M Cunha, V Neto, V Hespanhol, D F Martins, S Guimarães, A Varela, and D Carvalho

to excision of the cervical lesion ( Fig. 3 ). Immunohistochemistry studies were performed and staining was positive for synaptophysin, chromogranin, and S-100 protein and negative for Cytokeratin 8/18. Ki67 Proliferative Index was between 1 and 3

Open access

Tu Vinh Luong, Zaibun Nisa, Jennifer Watkins, and Aimee R Hayes

. Immunohistochemistry showed positivity of the LCNEC for pancytokeratins, chromogranin ( Fig. 2A ), synaptophysin, CD56 and CDX2. Overexpression of p53 was seen. The proliferation index with Ki-67 was high, approximately 70% ( Fig. 2B ). There was no host lymphoid

Open access

Sarah Y Qian, Matthew J L Hare, Alan Pham, and Duncan J Topliss

–10%, consistent with a grade 2 lesion by WHO classification ( 3 ). Immunohistochemistry was positive for the presence of chromogranin and synaptophysin, but paradoxically negative for the presence of insulin ( Fig. 4 ). There were no features of nesidioblastosis

Open access

Seong Keat Cheah, David Halsall, Peter Barker, John Grant, Abraham Mathews, Shyam Seshadri, and Singhan Krishnan

) confirmed clear cell renal carcinoma with strong cytoplasmic staining for RCC, whilst insulin, chromogranin A and synaptophysin relevant for neuroendocrine tumour were negative. Figure 2 Kidney tumour. (A) H&E staining (×10). (B) Synaptophysin staining

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Taiba Zornitzki, Hadara Rubinfeld, Lyudmila Lysyy, Tal Schiller, Véronique Raverot, Ilan Shimon, and Hilla Knobler

centrally located round oval nuclei, eosinophilic cytoplasm and no mitoses. Immunohistochemical staining was positive for pankeratin, chromogranin A and synaptophysin. KI-67 index was 5%. Ga-68 DOTATATE PET scan depicted strong Ga-68 uptake in the pancreatic

Open access

Tiago Nunes da Silva, (Loes) M L F van Velthuysen, Casper H J van Eijck, Jaap J Teunissen, (Hans) J Hofland, and Wouter W de Herder

%) with positive immunostaining for chromogranin, synaptophysin and the somatostatin receptor subtype 2a (SSTR2A) receptor. Figure 1 Abdominal CT before PPRT (A) and after PPRT (B) and after surgery (C). Abdominal CT showing a 12.8 cm pancreatic NET

Open access

Shanika Samarasinghe, Simge Yuksel, and Swati Mehrotra

both lobes of the thyroid gland. No mixed primary tumor was discovered within the thyroid gland. Immunohistochemical stains for calcitonin, thyroglobulin (Tg), and synaptophysin were used to confirm the diagnosis. Tumor staging according to American

Open access

Sakshi Jhawar, Rahul Lakhotia, Mari Suzuki, James Welch, Sunita K Agarwal, John Sharretts, Maria Merino, Mark Ahlman, Jenny E Blau, William F Simonds, and Jaydira Del Rivero

synaptophysin, chromogranin, CD56 and TTF1, but were negative for neuron-specific enolase, calcitonin, serotonin and gastrin ( Fig. 1 ). Figure 1 (A) Dermoid cyst from patient’s first surgery with elements of hair follicles (arrowhead). Fat cells (star