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Mariana Aveiro-Lavrador, Adriana De Sousa Lages, Luísa Barros, and Isabel Paiva

Endocrinology, Urology and Radiology medical teams. Figure 3 Scrotal and testicular ultrasound revealing a 12.9 mm hypoechogenic nodular formation in the left testicular tissue. Table 2 Biochemical markers for testicular cancer evaluation

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Paweena Chunharojrith, Kanapon Pradniwat, and Tanawan Kongmalai

Urology 2019 26 9956 – 9959 . 9 Palapattu GS Kristo B Rajfer J Paraneoplastic syndromes in urologic malignancy: the many faces of renal cell carcinoma . Reviews in Urology 2002 4 163 – 170 . 10 Salgado LR Fragoso MC

Open access

Ryizan Nizar, Nathan W P Cantley, and Jonathan C Y Tang

– first presenting at age 12 while still living in Egypt. Subsequent repeat renal calculi developed at age 16 and 17. The patient had an otherwise normal development history since his childhood. He then presented to urology services in the UK as an adult

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Nam Quang Tran, Chien Cong Phan, Thao Thi Phuong Doan, and Thang Viet Tran

:// ) 4 Soedarso MA Nugroho KH Dewi KAM . A case report: Addison disease caused by adrenal tuberculosis . Urology Case Reports 2018 20 12 – 14 . ( ) 5 Lam KY Lo CY . A

Open access

Shunsuke Shimazaki, Itsuro Kazukawa, Kyoko Mori, Makiko Kihara, and Masanori Minagawa

contemporary cohort . Urology 2017 102 43 – 47 . ( ) 3 Dick WH Lingeman JE Preminger GM Smith LH Wilson DM Shirrell WL Laxative abuse as a cause for ammonium urate renal calculi . Journal of

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Marinos C Makris, Konstantinos C Koumarelas, Apostolos S Mitrousias, Giannos G Psathas, Athanasios Mantzioros, Stratigoula P Sakellariou, Panagiota Ntailiani, and Evripides Yettimis

of an intrascrotal mass . Archives of Pathology & Laboratory Medicine 133 811 – 813 . Richie JP 1998 Neoplasms of testis. In Campbells' Urology , vol 3, ch 78, 7th edn, pp 2411–2452. Eds PC Walsh, AB Retic, ED Vangham, AJ Nein et al

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Geetanjali Kale, Elaine M Pelley, and Dawn Belt Davis

Adrenal myelolipoma: diagnosis and management . Urology Journal 3 71 – 74 . Vick CW Zeman RK Mannes E Cronan JJ & Walsh JW 1984 Adrenal myelolipoma: CT and ultrasound findings . Urologic Radiology

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J Rajkanna, S Tariq, and S O Oyibo

617 – 624 . ( doi:10.1530/eje.0.1470617 ) Crosnoe LE Grober E Ohl D & Kim ED 2013 Exogenous testosterone: a preventable cause of male infertility . Translational Andrology and Urology 2 106 – 113

Open access

Eriselda Profka, Giulia Rodari, Federico Giacchetti, Alfredo Berrettini, Gianantonio Manzoni, Valeria Daccò, Maura Arosio, Claudia Giavoli, and Carla Colombo


An 8-year-old boy with cystic fibrosis came to our attention for an empty scrotum. General physical examination showed a normal penis and hypoplastic scrotum with non-palpable testes bilaterally. Routine blood investigations showed low levels of LH, testosterone, inhibin B and antiMullerian hormone and elevated levels of FSH. Karyotype was normal. An abdominal ultrasound confirmed the absence of the testes into the scrotum, in the inguinal region and abdomen. At laparoscopy were noted bilaterally hypotrophic spermatic vessels, absence of the vas deferens and a closed inner ring. Inguinal exploration found out a small residual testis and histological examination showed fibrotic tissue. This is the first case of testicular atrophy associated to CFTR mutation described. The process that led to bilateral testicular and vas deferens atrophy remains unexplained, a possible influence of CFTR dysfunction cannot be ruled out, although it is possible that these conditions are independently associated.

Learning points:

  • Cystic fibrosis produces a multisystemic disease which can affect also the reproductive tract.

  • Nearly 97–98% of male patients are infertile because of congenital bilateral absence of vas deferens.

  • A correlation between cystic fibrosis and bilateral testicular atrophy could be possible.

Open access

Mariana Barbosa, Sílvia Paredes, Maria João Machado, Rui Almeida, and Olinda Marques

:// ) 6 Ito Y . Unexpected enlargement of clinically silent pituitary gonadotroph adenoma induced by goserelin acetate given as treatment for prostate cancer . International Journal of Urology 2011 18 83 – 84