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Andrew R Tang Division of Endocrinology, Department of Medicine, University of Calgary, Calgary, Alberta, Canada

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Laura E Hinz Division of Endocrinology, Department of Medicine, University of Calgary, Calgary, Alberta, Canada

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Aneal Khan Department of Medical Genetics and Pediatrics, University of Calgary, Alberta Children’s Hospital Research Institute, Calgary, Alberta, Canada

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Gregory A Kline Division of Endocrinology, Department of Medicine, University of Calgary, Calgary, Alberta, Canada

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.51 mmol/L (normal 2.18–2.54 mmol/L) with hypercalcuria of 0.15 mmol/kg/day (normal <0.10). At presentation, her serum phosphate was in the age-specific normal range at 1.39 mmol/L (normal 1.29–1.94 mmol/L) and remained normal up to age 11 years when she

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Hans-Christof Schober Departments of Internal Medicine
Endocrinology, Rheumatology/Immunology, Klinikum Südstadt Rostock, Rostock, Germany

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Christian Kneitz Endocrinology, Rheumatology/Immunology, Klinikum Südstadt Rostock, Rostock, Germany

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Franziska Fieber Endocrinology, Rheumatology/Immunology, Klinikum Südstadt Rostock, Rostock, Germany

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Kathrin Hesse Departments of Internal Medicine
Endocrinology, Rheumatology/Immunology, Klinikum Südstadt Rostock, Rostock, Germany

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Henry Schroeder Department of Neurosurgery, Universitätsmedizin Greifswald, Greifswald, Germany

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abnormal production of FGF-23, and phosphate is eliminated to a greater extent ( 1 ). Phosphate and calcium are linked to each other in blood as a calcium–phosphate product. The reduction of serum phosphate levels impairs the calcification of bone, and

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Carmina Teresa Fuss Division of Endocrinology and Diabetology, Department of Medicine I, University Hospital Würzburg, Würzburg, Germany

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Stephanie Burger-Stritt Division of Endocrinology and Diabetology, Department of Medicine I, University Hospital Würzburg, Würzburg, Germany

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Silke Horn Division of Endocrinology and Diabetology, Department of Medicine I, University Hospital Würzburg, Würzburg, Germany

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Ann-Cathrin Koschker Division of Endocrinology and Diabetology, Department of Medicine I, University Hospital Würzburg, Würzburg, Germany

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Kathrin Frey Division of Endocrinology and Diabetology, Department of Medicine I, University Hospital Würzburg, Würzburg, Germany

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Almuth Meyer Division of Endocrinology and Diabetology, Department of Internal Medicine, Helios Klinikum Erfurt, Erfurt, Germany

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Stefanie Hahner Division of Endocrinology and Diabetology, Department of Medicine I, University Hospital Würzburg, Würzburg, Germany

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elevated serum phosphate levels ( 3 ). In a recent study, PTH administration was safe, tolerable and effective over a period of 5 years ( 4 ). Because PTH injection once a day often does not lead to stable calcium concentration, PTH was applied multiple

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Maria P Yavropoulou Division of Clinical and Molecular Endocrinology, 1st Department of Internal Medicine, AHEPA University Hospital, Aristotle University of Thessaloniki, 1 Stilponos, Kyriakidi Street, Thessaloniki, 54636, Greece

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Nikolina Gerothanasi Division of Clinical and Molecular Endocrinology, 1st Department of Internal Medicine, AHEPA University Hospital, Aristotle University of Thessaloniki, 1 Stilponos, Kyriakidi Street, Thessaloniki, 54636, Greece

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Athanasios Frydas Division of Clinical and Molecular Endocrinology, 1st Department of Internal Medicine, AHEPA University Hospital, Aristotle University of Thessaloniki, 1 Stilponos, Kyriakidi Street, Thessaloniki, 54636, Greece

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Evangelia Triantafyllou Division of Clinical and Molecular Endocrinology, 1st Department of Internal Medicine, AHEPA University Hospital, Aristotle University of Thessaloniki, 1 Stilponos, Kyriakidi Street, Thessaloniki, 54636, Greece

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Chris Poulios Pathology Department, Faculty of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece

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Prodromos Hytiroglou Pathology Department, Faculty of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece

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Panagiotis Apostolou Research Genetic Cancer Centre Ltd (RGCC Ltd), Florina, Greece

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Ioannis Papasotiriou Research Genetic Cancer Centre Ltd (RGCC Ltd), Florina, Greece

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Symeon Tournis Laboratory of Research of Musculoskeletal System ‘Th. Garofalidis’, Medical School, KAT Hospital, University of Athens, Athens, Greece

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Isaak Kesisoglou 3rd Department of Surgery, AHEPA University Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece

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John G Yovos Division of Clinical and Molecular Endocrinology, 1st Department of Internal Medicine, AHEPA University Hospital, Aristotle University of Thessaloniki, 1 Stilponos, Kyriakidi Street, Thessaloniki, 54636, Greece

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phosphate from the urine. There were no signs of glycosuria, aminoaciduria or proteinuria. MRI located a tumor in the periphery of the head and the upper third of the left fibular diaphysis ( Fig. 1 ). Serum FGF23 levels were as high as 74 000 pg

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Eseoghene Ifie Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford, UK

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Samson O Oyibo Department of Endocrinology, Peterborough City Hospital, Peterborough, UK

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Hareesh Joshi Department of Endocrinology, Peterborough City Hospital, Peterborough, UK

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Olugbenro O Akintade Department of Elderly Care Medicine, Peterborough City Hospital, Peterborough, UK

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who prescribe this iron product. Ferric carboxymaltose infusion therapy causes renal wasting of phosphate. It has been suggested that this iron compound increases serum levels of fibroblast growth factor 23 (FGF23) by inhibiting FGF23 degradation

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Katsumi Taki Department of Internal Medicine, Fujiyoshida Municipal Medical Center, Yamanashi, 403-0005, Japan

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Takahiko Kogai Department of Infection Control and Clinical Laboratory Medicine, Dokkyo Medical University, Tochigi, 321-0293, Japan

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Junko Sakumoto Department of Infection Control and Clinical Laboratory Medicine, Dokkyo Medical University, Tochigi, 321-0293, Japan

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Takashi Namatame Clinical Research Center, Dokkyo Medical University, Tochigi, 321-0293, Japan

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Akira Hishinuma Department of Infection Control and Clinical Laboratory Medicine, Dokkyo Medical University, Tochigi, 321-0293, Japan

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; reference values 8.8–10.8), mild hypophosphatemia (serum phosphate 2.6 mg/dl; reference values 2.7–4.4), normal intact PTH levels (34 pg/ml; reference values 10–65), and relative hypocalciuria (fractional extraction of calcium (FECa) 1.07%). Serum

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Maria P Yavropoulou Division of Endocrinology and Metabolism, 1st Department of Internal Medicine, AHEPA University Hospital, Thessaloniki, Greece

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Christos Poulios Department of Pathology, Faculty of Medicine, Aristotle University of Thessaloniki, Greece

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Christoforos Foroulis Department of Thoracic Surgery, AHEPA University Hospital, Thessaloniki, Greece

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Symeon Tournis Laboratory of Research of Musculoskeletal System ‘Th. Garofalidis’, KAT Hospital University of Athens, Greece

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Prodromos Hytiroglou Department of Pathology, Faculty of Medicine, Aristotle University of Thessaloniki, Greece

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Kalliopi Kotsa Division of Endocrinology and Metabolism, 1st Department of Internal Medicine, AHEPA University Hospital, Thessaloniki, Greece

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Isaak Kessisoglou 3rd Department of Surgery, AHEPA University Hospital, Thessaloniki, Greece

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