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Primary hyperparathyroidism due to atypical vertically long cystic adenoma

Sachiko-Tsukamoto Kawashima Department of Endocrinology and Metabolism, National Hospital Organization Kyoto Medical Center, Kyoto, Japan
Department of Diabetes, Endocrinology and Metabolism Tango Central Hospital, Kyoto, Japan

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Takeshi Usui Clinical Research Institute

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Yohei Ueda Department of Endocrinology and Metabolism, National Hospital Organization Kyoto Medical Center, Kyoto, Japan

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Maiko-Kakita Kobayashi Department of Endocrinology and Metabolism, National Hospital Organization Kyoto Medical Center, Kyoto, Japan

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Mika Tsuiki Department of Endocrinology and Metabolism, National Hospital Organization Kyoto Medical Center, Kyoto, Japan

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Kanako Tanase-Nakao Department of Endocrinology and Metabolism, National Hospital Organization Kyoto Medical Center, Kyoto, Japan

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Kazutaka Nanba Department of Endocrinology and Metabolism, National Hospital Organization Kyoto Medical Center, Kyoto, Japan

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Tetsuya Tagami Department of Endocrinology and Metabolism, National Hospital Organization Kyoto Medical Center, Kyoto, Japan

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Mitsuhide Naruse Clinical Research Institute

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Yoshiki Watanabe Department of Head and Neck Surgery, National Hospital Organization Kyoto Medical Center, 1-1 Mukaihata-cho, Fukakusa, Fushimi-ku, Kyoto 612-8555, Japan

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Ryo Asato Department of Head and Neck Surgery, National Hospital Organization Kyoto Medical Center, 1-1 Mukaihata-cho, Fukakusa, Fushimi-ku, Kyoto 612-8555, Japan

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Sumiko Kato Osaka Saiseikai Ibaraki Hospital, Osaka, Japan

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Akira Shimatsu Clinical Research Institute

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asymptomatic hypercalcemia. Routine preoperative diagnostic tools, such as ultrasonography (US) or 99m technetium-sestamibi (99mTc-MIBI) scans, cannot clearly distinguish between these entities (2) . We report a hypercalcemic patient with a cervical cystic

Taxonomy:
Clinical Overview, Gland/Organ, Parathyroid, Topic, Tumours and neoplasia, Hormone, PTH, Condition/ Syndrome, Hyperparathyroidism (primary), Parathyroid adenoma, Parathyroid cyst, Patient Demographics, Age, Adult, Gender, Female, Ethnicity, Asian - Japanese, Country of Treatment, Japan, Diagnosis and Treatment, Signs and Symptoms, Hypercalcaemia, Investigation, Calcium (serum), Calcium (urine), Calcium to creatinine clearance ratio, CT scan, PTH, Sestamibi scan, Ultrasound scan, Intervention, Parathyroidectomy, Related Disciplines, Oncology, Publication Details, Case Report Type, Unique/unexpected symptoms or presentations of a disease
DOI:
https://doi.org/10.1530/EDM-14-0086
Volume/Issue:
Volume 2014: Issue 1
Open access

Spontaneous cervical haemorrhage of a parathyroid adenoma

Lara Ulrich General Surgery, Kingston Hospital, London, UK

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Graham Knee Pathology, Kingston Hospital, London, UK

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Colin Todd Radiology, Kingston Hospital, London, UK

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impossible to exclude a malignancy on imaging alone. In order to exclude the possibility of a parathyroid carcinoma and treat her hypercalcaemia, she was referred for elective surgery. Figure 2 Subtraction sestamibi nuclear medicine scan showing a

Taxonomy:
Clinical Overview, Gland/Organ, Parathyroid, Topic, Endocrine-related cancer, Hormone, PTH, Condition/ Syndrome, Haemorrhage, Hyperparathyroidism (primary), Parathyroid adenoma, Patient Demographics, Age, Adult, Gender, Female, Ethnicity, White, Country of Treatment, United Kingdom, Diagnosis and Treatment, Signs and Symptoms, Cervical pain, Dysphonia, Ecchymoses, Hypercalcaemia, Investigation, Calcium (serum), CT scan, Histopathology, PTH, Sestamibi scan, Surgical biopsy, Ultrasound scan, Related Disciplines, Radiology/Rheumatology, Surgery, Publication Details, Case Report Type, Unique/unexpected symptoms or presentations of a disease
DOI:
https://doi.org/10.1530/EDM-15-0034
Volume/Issue:
Volume 2015: Issue 1
Open access

Late bone metastasis from an apparently benign oncocytic follicular thyroid tumor

Mauro Boronat Section of Endocrinology and Nutrition

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Juan J Cabrera Service of Pathology, Complejo Hospitalario Universitario Insular Materno-Infantil, Avenida Marítima del Sur, s/n. 35016 Las Palmas de Gran Canaria, Spain

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Carmen Perera Service of Nuclear Medicine, Hospital General de Gran Canaria Dr Negrín. Plaza Barranco de la Ballena, s/n. 35012 Las Palmas de Gran Canaria, Spain

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Concepción Isla Service of Nuclear Medicine, Complejo Hospitalario Universitario Insular Materno-Infantil, Avenida Marítima del Sur, s/n. 35016 Las Palmas de Gran Canaria, Spain

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Francisco J Nóvoa Section of Endocrinology and Nutrition

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-abdominal CT scan were negative. A 99m Tc SestaMIBI WBS disclosed a well-delimited focal uptake in the distal region of the right femur ( Fig. 1 ). A FDG-PET/CT study performed after rhTSH stimulation showed lytic resorption in the left iliac crest, just above

Taxonomy:
Clinical Overview, Gland/Organ, Bone, Thyroid, Topic, Bone, Endocrine-related cancer, Thyroid, Tumours and neoplasia, Condition/ Syndrome, Follicular thyroid cancer, Metastatic carcinoma, Papillary thyroid cancer, Thyroid adenoma, Patient Demographics, Age, Geriatric, Gender, Male, Ethnicity, White, Country of Treatment, Italy, Spain, Diagnosis and Treatment, Investigation, Biopsy, Bone scintigraphy, Histopathology, PET scan, Sestamibi scan, Thyroglobulin, Intervention, Radiotherapy, Medication, Bisphosphonates, Zoledronic acid, Related Disciplines, Oncology, Pathology, Radiology/Rheumatology, Publication Details, Case Report Type, Error in diagnosis/pitfalls and caveats
DOI:
https://doi.org/10.1530/EDM-13-0051
Volume/Issue:
Volume 2013: Issue 1
Open access

A rare ophthalmic condition associated with primary hyperparathyroidism (PHPT): sclerochoroidal calcification (SC)

Mona Abouzaid Department of Diabetes and Endocrinology, South Tyneside and Sunderland NHS Foundation Trust, Sunderland, UK

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Ahmed Al-Sharefi Department of Diabetes and Endocrinology, South Tyneside and Sunderland NHS Foundation Trust, Sunderland, UK

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Satish Artham Department of Diabetes and Endocrinology, South Tyneside and Sunderland NHS Foundation Trust, Sunderland, UK
Department of Endocrinology and Diabetes, North Tees and Hartlepool Hospitals NHS Foundation Trust, Hartlepool, UK

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Ibrahim Masri Sunderland Eye Infirmary, South Tyneside and Sunderland NHS Foundation Trust, Sunderland, UK

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Ajay Kotagiri Sunderland Eye Infirmary, South Tyneside and Sunderland NHS Foundation Trust, Sunderland, UK

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Ashwin Joshi Department of Diabetes and Endocrinology, South Tyneside and Sunderland NHS Foundation Trust, Sunderland, UK

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ultrasonography, high-resolution computed tomography (CT) and technetium sestamibi scan of the neck. An ultrasound of the abdomen showed no nephrocalcinosis but a bone densitometry scan confirmed a diagnosis of osteoporosis which was mostly affecting the distal

Taxonomy:
Clinical Overview, Gland/Organ, Bone, Topic, Bone, Hormone, PTH, Condition/ Syndrome, Hypercalcaemia, Hyperparathyroidism (primary), Osteoporosis, Parathyroid adenoma, Patient Demographics, Age, Geriatric, Gender, Male, Ethnicity, White, Country of Treatment, United Kingdom, Diagnosis and Treatment, Signs and Symptoms, Hypercalcaemia, Osteoporosis, Investigation, Calcium (serum), CT scan, DEXA scan, Estimated glomerular filtration rate, OCT, Phosphate (serum), PTH, Sestamibi scan, Ultrasound scan, Medication, Bisphosphonates, Related Disciplines, Ophthalmology, Publication Details, Case Report Type, Unique/unexpected symptoms or presentations of a disease
DOI:
https://doi.org/10.1530/EDM-19-0003
Volume/Issue:
Volume 2019: Issue 1
Open access

Benefits of 11C-methionine PET/MRI and intraoperative fluorescence in treating hyperparathyroidism

Thien Vinh Luong Department of Nuclear Medicine and PET-Centre, Aarhus University Hospital, Aarhus, Denmark

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Lars Rejnmark Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark

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Anne Kirstine Arveschoug Department of Nuclear Medicine and PET-Centre, Aarhus University Hospital, Aarhus, Denmark

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Peter Iversen Department of Nuclear Medicine and PET-Centre, Aarhus University Hospital, Aarhus, Denmark

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Lars Rolighed Department of Otorhinolaryngology, Aarhus University Hospital, Aarhus, Denmark

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, depression, and tiredness. Treatment of primary HPT in MEN1 patients usually involves preoperative localization of enlarged PGs, typically with ultrasonography (US) and a 99m Tc-sestamibi scintigraphy (MIBI) often combined with a single photon emission and a

Taxonomy:
Clinical Overview, Gland/Organ, Parathyroid, Hormone, PTH, Condition/ Syndrome, Hypercalcaemia, Hyperparathyroidism (primary), MEN1, Parathyroid adenoma, Patient Demographics, Age, Paediatric, Gender, Female, Ethnicity, White, Country of Treatment, Denmark, Diagnosis and Treatment, Signs and Symptoms, Headache, Hypercalcaemia, Investigation, Angiography, Calcium (serum), MRI, PET scan, PTH, Sestamibi scan, Ultrasound scan, Intervention, Parathyroidectomy, Related Disciplines, Genetics, Paediatrics, Publication Details, Case Report Type, Novel diagnostic procedure
DOI:
https://doi.org/10.1530/EDM-20-0053
Volume/Issue:
Volume 2020: Issue 1
Open access

The use of cinacalcet in pregnancy to treat a complex case of parathyroid carcinoma

K Nadarasa Department of Endocrinology, St Bartholomew's Hospital, London, UK

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M Bailey Department of Endocrinology, St Bartholomew's Hospital, London, UK

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H Chahal Imperial Centre for Endocrinology, Imperial College Healthcare NHS Trust, London, UK

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O Raja Department of Endocrinology, St Bartholomew's Hospital, London, UK

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R Bhat Department of Neonatology, King's College Hospital, London, UK

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C Gayle Department of Diabetes, King's College Hospital, London, UK

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A B Grossman Department of Endocrinology, St Bartholomew's Hospital, London, UK

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M R Druce Department of Endocrinology, St Bartholomew's Hospital, London, UK

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ultrasound scan of the parathyroid glands and Technetium-99m sestamibi imaging confirmed an abnormal right upper parathyroid gland. The patient underwent a parathyroidectomy and the histology revealed a 15×12×18 mm parathyroid carcinoma extending to the

Taxonomy:
Clinical Overview, Gland/Organ, Parathyroid, Topic, Endocrine-related cancer, Hormone, PTH, Condition/ Syndrome, Brown tumour, Hypercalcaemia, Hypocalcaemia, Metastatic carcinoma, Parathyroid carcinoma, Pregnancy, Patient Demographics, Age, Adult, Neonatal, Gender, Female, Ethnicity, White, Country of Treatment, United Kingdom, Diagnosis and Treatment, Signs and Symptoms, Bone pain, Constipation, Fatigue, Polydipsia, Polyuria, Investigation, Calcium (serum), CT scan, PET scan, PTH, Sestamibi scan, Ultrasound scan, Intervention, Lymphadenectomy, Parathyroidectomy, Radiofrequency ablation, Medication, Bisphosphonates, Calcimimetics, Cinacalcet, Zoledronic acid, Related Disciplines, Obstetrics, Publication Details, Case Report Type, Novel treatment
DOI:
https://doi.org/10.1530/EDM-14-0056
Volume/Issue:
Volume 2014: Issue 1
Open access

Should all patients with hyperparathyroidism be screened for a CDC73 mutation?

Caroline Bachmeier Endocrinology Department, Townsville Hospital, Townsville, Queensland, Australia

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Chirag Patel Genetic Health Queensland, Royal Brisbane and Women’s Hospital, Herston, Queensland, Australia

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Peter Kanowski Clinical Pathology/Histopathology, Sullivan Nicolaides Pathology, Townsville, Queensland, Australia

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Kunwarjit Sangla Endocrinology Department, Townsville Hospital, Townsville, Queensland, Australia
James Cook University, Townsville, Queensland, Australia

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.06–0.45). 25-Hydroxycholecalciferol was 67 nmol/L (50–150 nmol/L). A parathyroid scan including pertechnate and Tc99m Sestamibi with early and delayed SPECT/CT of neck and mediastinum showed a solitary parathyroid adenoma in the lower pole of the left lobe of

Taxonomy:
Clinical Overview, Gland/Organ, Parathyroid, Topic, Bone, Hormone, PTH, Condition/ Syndrome, Hyperparathyroidism (primary), Parathyroid adenoma, Patient Demographics, Age, Adult, Gender, Female, Ethnicity, White, Country of Treatment, Australia, Diagnosis and Treatment, Investigation, Calcium (urine), Calcium to creatinine clearance ratio, CT scan, Histopathology, Microarray analysis, Molecular genetic analysis, PTH, Sestamibi scan, SPECT scan, Intervention, Parathyroidectomy, Related Disciplines, Surgery, Publication Details, Case Report Type, Error in diagnosis/pitfalls and caveats
DOI:
https://doi.org/10.1530/EDM-17-0164
Volume/Issue:
Volume 2018: Issue 1
Open access

Two cases of spontaneous remission of primary hyperparathyroidism due to auto-infarction: different management and their outcomes

Peter Novodvorsky Department of Diabetes and Endocrinology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK
Department of Oncology and Metabolism, University of Sheffield, Sheffield, UK

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Ziad Hussein Department of Diabetes and Endocrinology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK

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Muhammad Fahad Arshad Department of Diabetes and Endocrinology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK

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Ahmed Iqbal Department of Diabetes and Endocrinology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK

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Malee Fernando Department of Histopathology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK

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Alia Munir Department of Diabetes and Endocrinology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK
Department of Oncology and Metabolism, University of Sheffield, Sheffield, UK

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Sabapathy P Balasubramanian Department of Oncology and Metabolism, University of Sheffield, Sheffield, UK
Department of General Surgery, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK

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of conditions, the most common being solitary thyroid adenoma, followed by benign and malignant lesions of the neck, breast or lung, thymic lesions or reactive lymph nodes ( 13 ). Although the sensitivity of the 99m Tc sestamibi scan is high in

Taxonomy:
Clinical Overview, Gland/Organ, Parathyroid, Topic, Bone, Hormone, PTH, Condition/ Syndrome, Hypercalcaemia, Hyperparathyroidism (primary), Parathyroid adenoma, Patient Demographics, Age, Adult, Gender, Female, Male, Ethnicity, Black - Caribbean, White, Country of Treatment, United Kingdom, Diagnosis and Treatment, Signs and Symptoms, Appetite reduction/loss, Fatigue, Hypercalcaemia, Hypophosphataemia, Paraesthesia, Weight loss, Investigation, Alkaline phosphatase, Bone mineral density, Calcium (serum), Calcium (urine), Creatinine (serum), CT scan, Fine needle aspiration biopsy, Histopathology, MRI, Phosphate (serum), PTH, Sestamibi scan, SPECT scan, Ultrasound scan, Urine 24-hour volume, Vitamin D, Intervention, Fluid repletion, Parathyroidectomy, Medication, Bisphosphonates, Calcium, Calcium carbonate, Cholecalciferol, Pamidronate, Saline, Vitamin D, Publication Details, Case Report Type, Unique/unexpected symptoms or presentations of a disease
DOI:
https://doi.org/10.1530/EDM-18-0136
Volume/Issue:
Volume 2019: Issue 1
Open access

Management of primary hyperparathyroidism in pregnancy: a case series

Aisling McCarthy University Hospital Galway, Galway, Ireland

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Sophie Howarth Department of Diabetes and Endocrinology, Cambridge University NHS Foundation Trust, Cambridge, UK

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Serena Khoo Department of Diabetes and Endocrinology, Cambridge University NHS Foundation Trust, Cambridge, UK

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Julia Hale Department of Diabetes and Endocrinology, Cambridge University NHS Foundation Trust, Cambridge, UK

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Sue Oddy Department of Clinical Biochemistry, Cambridge University NHS Foundation Trust, Cambridge, UK

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David Halsall Department of Clinical Biochemistry, Cambridge University NHS Foundation Trust, Cambridge, UK

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Brian Fish Department of Head and Neck Surgery, Cambridge University NHS Foundation Trust, Cambridge, UK

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Sashi Mariathasan Department of Diabetes and Endocrinology, Cambridge University NHS Foundation Trust, Cambridge, UK

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Katrina Andrews East Anglian Medical Genetics Service, Cambridge University Hospitals NHS Foundation Trust, Cambridge Biomedical Campus, Cambridge, UK

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Samson O Oyibo Department of Diabetes and Endocrinology, Peterborough City Hospital, North West Anglia NHS Foundation Trust, Peterborough, UK

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Manjula Samyraju Department of Obstetrics and Gynecology, Peterborough City Hospital, North West Anglia NHS Foundation Trust, Peterborough, UK

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Katarzyna Gajewska-Knapik Department of Obstetrics and Gynecology, Cambridge University NHS Foundation Trust, Cambridge, UK

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Soo-Mi Park East Anglian Medical Genetics Service, Cambridge University Hospitals NHS Foundation Trust, Cambridge Biomedical Campus, Cambridge, UK

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Diana Wood Department of Diabetes and Endocrinology, Cambridge University NHS Foundation Trust, Cambridge, UK

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Carla Moran Department of Diabetes and Endocrinology, Cambridge University NHS Foundation Trust, Cambridge, UK

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Ruth T Casey Department of Diabetes and Endocrinology, Cambridge University NHS Foundation Trust, Cambridge, UK
Department of Medical Genetics, Cambridge University, Cambridge, UK

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is limited in pregnancy as computed tomography and the gold standard 99mTc Sestamibi scan are contraindicated because of the radiation risk to the foetus, and therefore, ultrasound remains the only suitable radiological imaging modality in pregnancy

Taxonomy:
Clinical Overview, Gland/Organ, Bone, Topic, Bone, Hormone, PTH, Condition/ Syndrome, Gestational diabetes mellitus, Hypercalcaemia, Hyperparathyroidism (primary), MEN1, Parathyroid adenoma, Parathroid hyperplasia, Patient Demographics, Age, Pregnant adult, Gender, Female, Ethnicity, White, Country of Treatment, United Kingdom, Diagnosis and Treatment, Signs and Symptoms, Abdominal discomfort, Diarrhoea, Fatigue, Headache, Hypercalcaemia, Nausea, Polydipsia, Polyuria, Vomiting, Investigation, Calcium (serum), Calcium to creatinine clearance ratio, CT scan, Histopathology, Molecular genetic analysis, Phosphate (serum), PTH, Sestamibi scan, SPECT scan, Ultrasound scan, Vitamin D, Intervention, Diet, Fluid repletion, Parathyroidectomy, Publication Details, Case Report Type, Novel diagnostic procedure
DOI:
https://doi.org/10.1530/EDM-19-0039
Volume/Issue:
Volume 2019: Issue 1
Open access

Needle aspirate PTH in diagnosis of primary hyperparathyroidism due to intrathyroidal parathyroid cyst

Deep Dutta Departments of Endocrinology and Metabolism

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Chitra Selvan Departments of Endocrinology and Metabolism

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Manoj Kumar Departments of Endocrinology and Metabolism

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Saumik Datta Departments of Endocrinology and Metabolism

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Ram Narayan Das Pathology, IPGMER and SSKM Hospital, Room-9A, 4th Floor Ronald Ross Building, 244 AJC Bose Road, Calcutta 700020, India

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Sujoy Ghosh Departments of Endocrinology and Metabolism

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Satinath Mukhopadhyay Departments of Endocrinology and Metabolism

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Subhankar Chowdhury Departments of Endocrinology and Metabolism

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thyroid cyst. Six milliliters of serous fluid were aspirated, iPTH measurement from which revealed a level of 3480 pg/ml. Figure 2 Tc 99m sestamibi scan did not reveal any functional parathyroid adenoma. Poor radiotracer uptake in the lower pole and

Taxonomy:
Clinical Overview, Gland/Organ, Parathyroid, Topic, Mineral, Hormone, PTH, Condition/ Syndrome, Ectopic parathyroid adenoma, Hyperparathyroidism (primary), Parathyroid adenoma, Thyroid cyst, Patient Demographics, Age, Adult, Gender, Female, Ethnicity, Asian - Indian, Country of Treatment, India, Diagnosis and Treatment, Investigation, Fine needle aspiration biopsy, Sestamibi scan, Intervention, Thyroidectomy, Medication, Calcitriol, Related Disciplines, Surgery, Publication Details, Case Report Type, Novel diagnostic procedure
DOI:
https://doi.org/10.1530/EDM-13-0019
Volume/Issue:
Volume 2013: Issue 1
Open access